High-content Imaging

High-content imaging systems ranging from automated digital microscopy to high-throughput confocal imaging systems

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High-content Imaging

High-content imaging (HCI) systems

Our high-content imaging systems range from automated digital microscopy to high-throughput confocal imaging systems and feature best-in-class technology to optimize imaging capabilities for live cell imaging, hypoxia studies, thick cell samples, and multiplexed assays.
Introduction to the Organoid Innovation Center and ImageXpress Confocal HT.ai system

ImageXpress Confocal HT.ai system

Powerful multi-laser light sources, a deep tissue penetrating confocal disk module, water immersion objectives and modern machine learning analysis software

  • Ideal for highly-complex cell-based and 3D assays
  • Seven-channel high-intensity lasers generating brighter images with higher signal-to-background
  • Spinning confocal disk technology for deeper tissue penetration, resulting in sharper images with improved resolution
  • Water immersion objectives offering quadruple the signal at lower exposure times for greater sensitivity and image clarity without sacrificing speed
  • Optional IN Carta software, leveraging intuitive, modern machine learning

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ImageXpress Confocal HT.ai
https://main--moleculardevices--hlxsites.hlx.page/products/cellular-imaging-systems/high-content-imaging/imagexpress-confocal-ht-ai

ImageXpress Micro Confocal system

High-content confocal imaging solution with proprietary spinning disk technology and water objective options

  • Ideal for 3D organoid and spheroid imaging
  • Proprietary AgileOptix™ spinning disk technology
  • QuickID reduces image acquisition time and data storage requirements
  • Water immersion objectives enhance resolution, sensitivity and throughput of complex
    3D assays
  • Lasers and deep tissue confocal disk provide deeper penetration into 3D samples
  • 3D volumetric analysis

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ImageXpress Micro 4
https://main--moleculardevices--hlxsites.hlx.page/products/cellular-imaging-systems/high-content-imaging/imagexpress-micro-confocal

ImageXpress Micro 4 system

Configurable, high-throughput widefield imaging for fast biological processes

  • Ideal for high-throughput screening, time-lapse imaging (from calcium assays to
    multi-day subcellular assays) and intracellular yeast assays
  • Multiple imaging modes, including fluorescence, phase contrast, and brightfield
  • >3 log dynamic range intensity detection
  • QuickID reduces image acquisition time and data storage requirements
  • Environmental control option for live cell assays and fast kinetic studies
  • Field upgradeable to confocal

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ImageXpress Micro 4
https://main--moleculardevices--hlxsites.hlx.page/products/cellular-imaging-systems/high-content-imaging/imagexpress-micro-4

ImageXpress Nano

Fluorescence imaging, widefield platform for common biological assays

  • Ideal for phagocytosis, mitotoxicity, autophagy, and cell differentiation
  • Label-free brightfield imaging mode
  • Up to five fluorescent filters can be installed, enabling multi-channel fluorescent and transmitted light imaging in one experiment
  • High-speed autofocus
  • Environmental control option for multi-day time lapse and live cell assays

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ImageXpress Nano
https://main--moleculardevices--hlxsites.hlx.page/products/cellular-imaging-systems/high-content-imaging/imagexpress-nano

ImageXpress Pico system

Digital microscopy with automated brightfield, fluorescence, and real-time deconvolution imaging

  • Ideal for cell counting, transfection efficiency, and cell health assays
  • 25+ preconfigured application protocols
  • 3D z-stack acquisition
  • On-the-fly analysis
  • Environmental control for live cell assays
  • Access data from a browser— anytime, anywhere
  • Optional Digital Confocal on-the-fly 2D deconvolution

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ImageXpress Pico Automated Cell Imaging System
https://main--moleculardevices--hlxsites.hlx.page/products/cellular-imaging-systems/high-content-imaging/imagexpress-pico

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