High-content Imaging
High-content imaging systems ranging from automated digital microscopy to high-throughput confocal imaging systems
High-content imaging (HCI) systems
High-content imaging is an advanced technique used in cellular imaging systems to capture and analyze extensive visual data from biological samples. It combines cutting-edge microscopy technology, sophisticated image analysis algorithms, and powerful data processing capabilities to rapidly quantify multiple parameters relating to cellular structures, functions, and responses.
Our ImageXpress® high-content imaging systems range from automated digital microscopy to high-throughput confocal imaging systems. Our state-of-the-art AgileOptix™ technology combines an advanced solid-state light engine, water immersion objectives, a scientific CMOS sensor, and proprietary, dual-spinning disk technology. These systems allow researchers to explore the complex world of cellular biology, capturing high-resolution images of cells and subcellular components with a high level of accuracy and detail.
The acquired images are then subjected to in-depth analysis using high-content analysis (HCA) software. This software encompasses powerful algorithms that can extract a wide range of quantitative measurements. With our AI-enabled solutions, researchers can obtain valuable insights into various cellular features, including cell morphology, protein expression levels, subcellular localization, and cellular responses to different treatments or stimuli with increased efficiency.
One key advantage of high-content imaging is its high-throughput capabilities. Researchers can analyze large numbers of cells and images in a relatively short period, enabling them to study complex cellular processes at an unprecedented scale. This feature is particularly useful in drug discovery, toxicology studies, and basic research, as it allows for efficient screening of compounds or investigation of cellular mechanisms.
ImageXpress Confocal HT.ai system
Powerful multi-laser light sources, a deep tissue penetrating confocal disk module, water immersion objectives and modern machine learning analysis software
- Ideal for highly-complex cell-based and 3D assays
- Seven-channel high-intensity lasers generating brighter images with higher signal-to-background
- Spinning confocal disk technology for deeper tissue penetration, resulting in sharper images with improved resolution
- Water immersion objectives offering quadruple the signal at lower exposure times for greater sensitivity and image clarity without sacrificing speed
- Optional IN Carta software, leveraging intuitive, modern machine learning
ImageXpress Micro Confocal system
High-content confocal imaging solution with proprietary spinning disk technology and water objective options
- Ideal for 3D organoid and spheroid imaging
- Proprietary AgileOptix™ spinning disk technology
- QuickID reduces image acquisition time and data storage requirements
- Water immersion objectives enhance resolution, sensitivity and throughput of complex
3D assays - Lasers and deep tissue confocal disk provide deeper penetration into 3D samples
- 3D volumetric analysis
ImageXpress Micro 4 system
Configurable, high-throughput widefield imaging for fast biological processes
- Ideal for high-throughput screening, time-lapse imaging (from calcium assays to
multi-day subcellular assays) and intracellular yeast assays - Multiple imaging modes, including fluorescence, phase contrast, and brightfield
- >3 log dynamic range intensity detection
- QuickID reduces image acquisition time and data storage requirements
- Environmental control option for live cell assays and fast kinetic studies
- Field upgradeable to confocal
ImageXpress Nano
Fluorescence imaging, widefield platform for common biological assays
- Ideal for phagocytosis, mitotoxicity, autophagy, and cell differentiation
- Label-free brightfield imaging mode
- Up to five fluorescent filters can be installed, enabling multi-channel fluorescent and transmitted light imaging in one experiment
- High-speed autofocus
- Environmental control option for multi-day time lapse and live cell assays
ImageXpress Pico system
Digital microscopy with automated brightfield, fluorescence, and real-time deconvolution imaging
- Ideal for cell counting, transfection efficiency, and cell health assays
- 25+ preconfigured application protocols
- 3D z-stack acquisition
- On-the-fly analysis
- Environmental control for live cell assays
- Access data from a browser— anytime, anywhere
- Optional Digital Confocal on-the-fly 2D deconvolution
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