COVID-19 RESPONSE - We are committed to supporting our scientific community during this pandemic. Learn more 

High-Content Screening with AgileOptix Technology

Powerful solid-state lasers, water immersion objectives, scientific CMOS sensor, and dual spinning disk with five different disk geometries

High-throughput, high-content screening solution for complex 3D biology

The ImageXpress® Confocal systems feature the revolutionary AgileOptix® Spinning Disk Technology for high-content screening (HCS) that enables simple, user-defined configurations to ensure maximum assay performance for both confocal and widefield imaging. Multiple confocal geometries are available including pinhole and slit confocal imaging—the only commercially available high-content imaging system with this option.

AgileOptix HCS technology makes it possible for the system to deliver the sensitivity and throughput needed for demanding applications by combining an advanced solid-state light engine, proprietary spinning disk technology, state-of-the-art optics, and a scientific CMOS sensor. The system acquires a >3 log dynamic range and captures publication-quality images while its large optical field of view maximizes collection of statistically-relevant data. 

Increase imaging efficiency using our intelligent, QuickID Targeted Acquisition performed by the MetaXpress® software. For artificial intelligence (AI) analysis of complex 3D biology, IN Carta™ Image Analysis Software provides a streamlined workflow with powerful deep learning-based segmentation, machine learning-based classification, and 3D volumetric analysis.


Molecular Devices can successfully tailor ImageXpress Confocal systems to include customized software and hardware with the features described herein, as well as integration of other lab components such as incubators, liquid handlers, and robotics for a fully automated work cell. Check out our new Organoid Innovation Center where we showcase these cutting-edge technologies with novel 3D biology methods to address key challenges of scaling complex 3D biology.

Sales are subject to our Custom Product Purchase Terms available at



Learn how to overcome the challenges of high-throughput 3D imaging and analysis

Our high-content screening system with AgileOptix technology is a fully-integrated solution that addresses the many challenges associated with high-throughput 3D imaging. From out-of-focus haze or difficult light penetration to analysis bottlenecks and high-content data mining, we have a solution for you. With over 35 years of experience in the life science industry, you can count on us to deliver quality products and provide worldwide support.






  • 3D Cell Models

    3D Cell Models

    3D cell cultures offer the advantage of closely recapitulating aspects of human tissues including the architecture, cell organization, cell-cell and cell-matrix interactions, and more physiologically-relevant diffusion characteristics. Utilization of 3D cellular assays adds value to research and screening campaigns, spanning the translational gap between 2D cell cultures and whole-animal models. By reproducing important parameters of the in vivo environment, 3D models can provide unique insight into the behavior of stem cells and developing tissues in vitro.

    Read More 

    Cellular Imaging & Analysis

    Cell Imaging & Analysis

    Researchers have several options in methods for imaging cells, from phase-contrast microscopy that shows intact cells to fluorescent imaging of single molecules or organelles. Cellular analysis is performed to evaluate and measure the current state of cells, such as cell integrity, toxicity, and viability and various other research applications. An integral part of cellular analysis is data collection, analysis, and export into a meaningful and useful format.

    Learn more 

  • Cellular Imaging Systems

    Cellular Imaging Systems

    Our systems for high-content imaging (HCI) and high-content analysis (HCA) provide flexible scalability making it easy to evolve your system alongside your research. They feature options and modules to address your specific research including objectives, filters, imaging modes, and environmental conditions. All our systems support a wide range of applications, increased throughput, and streamlined workflows.

    Learn more 

    Organoid Innovation Center

    Organoid Innovation Center

    The new Organoid Innovation Center at Molecular Devices combines cutting-edge technologies with novel 3D biology methods to address key challenges of scaling complex 3D biology.

    The collaborative space brings customers and researchers into the lab to test automated workflows for organoid culturing and screening, with guidance from in-house scientists.

    Learn more 

Latest Resources

Resources for High Content Screening with AgileOptix™ Technology