ImageXpress Micro Confocal High-Content Imaging System
Unique confocal imaging solution capable of imaging more than a million wells a week
High-content imaging solution with proprietary spinning disc technology
The ImageXpress® Micro Confocal High-Content Imaging System is a high-content solution that can switch between confocal and widefield imaging of fixed and live cells. It captures high quality images of whole organisms, thick tissues, 2D and 3D models, and cellular or intracellular events. The spinning disc and sCMOS camera enable imaging of fast and rare events like cardiac cell beating and stem cell differentiation. With MetaXpress® software, it enables applications from 3D assay development to screening.
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Acquire higher quality images
Capture exceptional contrast, high resolution images with our proprietary AgileOptix™ Spinning Disc Technology, wide field of view, and bright light source.
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Customize image acquisition and analysis
Take ultimate control over acquisition and analysis parameters, which enable many applications from 3D structure analysis to targeted imaging of specific objects within an organism or cell populations.
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Analyze more data in less time
MetaXpress® PowerCore™ software accelerates analysis speed in a high-throughput environment. The software distributes image processing jobs to a multi-CPU environment.
ImageXpress Micro Confocal Video
Features
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Wide dynamic range
Quantifies low and high intensity signals in a single image with >3 log dynamic range intensity detection.
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Wide field of view
Wide field of view enables whole-well imaging and eliminates missed targets.
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Exclusive spinning disc technology
The technology provides increased sensitivity with custom optics, high-powered, solid state light engines, and sCMOS technology. Swappable disc geometries provide flexibility between speed and resolution.
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Accurate 3D measurements
MetaXpress 3D analysis module enables 3D measurements of volume and distance.
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Multiple imaging modes
The system offers phase contrast and brightfield label-free imaging, fluorescence, confocal, widefield, and colorimetric imaging.
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Optional on-board robotic fluidics
For assays that involve compound addition, well washing, and media exchange, optional on-board robotic fluidics are available.
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Product Brochure
ImageXpress Micro Confocal High-Content Imaging System
The ImageXpress Micro Confocal High-Content Imaging System provides improved quantification for live or fixed cell assays. This versatile imaging s…
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Product Brochure
MetaXpress High-Content Image Acquisition and Analysis Software
Capture high-resolution images, recognize and segment objects, calculate parameters, and then translate your information into meaningful data. At M…
Applications of ImageXpress Micro Confocal High-Content Imaging System
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Organ-on-a-Chip Assays
Emulating organ physiology by co-culturing cells in a supportive 3D matrix and using microfluidic channels to perfuse nutrients or compounds over the resulting cellular structures, is rapidly gaining popularity as a biologically relevant screening model for new drugs or toxicity. The ImageXpress system provides a turnkey solution for both 2D or 3D applications and can accommodate many different types of slide and plate formats.
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Neurite Outgrowth / Neurite Tracing
Neurons create connections via extensions of their cellular body called processes. This biological phenomenon is referred to as neurite outgrowth. Understanding the signaling mechanisms driving neurite outgrowth provides valuable insight into neurotoxic responses, compound screening, and for interpreting factors influencing neural regeneration. Using the ImageXpress Micro system in combination with MetaXpress Image Analysis Software automated neurite outgrowth imaging and analysis is possible for slide or microplate-based cellular assays.
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Spheroid Assays
Three-dimensional (3D) cells cultured into spheroids provide a more complete and physiologically predictive model especially for cancer research. Acquiring measurements from the larger structure involves acquiring images from different depths within the body of the spheroid and analyzing them in 3D or collapsing into a single 2D stack before analysis. The ImageXpress Micro system and MetaXpress software are designed to make acquisition and analysis of 3D spheroids fast and accurate.
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3D Cell Imaging and Analysis
Three-dimensional (3D) cell models are physiologically relevant and more closely represent tissue microenvironments, cell-to-cell interactions, and biological processes that occur in vivo. Now you can generate more predictive data by incorporating technologies like the ImageXpress system with the integrated 3D Analysis Module in MetaXpress® software. This single interface will enable you to meet 3D acquisition and analysis challenges without compromise to throughput or data quality, giving you confidence in your discoveries.
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3D Gel Matrix Assays
The development and integration of three-dimensional (3D) assay models are becoming popular to drive translational biology. Our ImageXpress system allows superior visualization of thick samples by minimizing background fluorescence and increasing sharpness, resulting in accurate image segmentation. Increase the biological relevance of your screening assays with a seamless integration between acquisition and analysis of cells in a 3D space to yield volume, intensity, and distance measurements.
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Toxicity Screening
Screening for off-target or toxic effects is very important during the development of new drugs and for the extension of the therapeutic potential of existing molecules. ImageXpress systems are fully integrated hardware and software platforms for automated acquisition and analysis of images for high-throughput cell-based cytotoxicity testing. Configured with optional environmental control, living cell responses or kinetic reactions can be monitored in real time for several days.
Specifications & Options of ImageXpress Micro Confocal High-Content Imaging System
Resources of ImageXpress Micro Confocal High-Content Imaging System
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Product Brochure
ImageXpress Micro Confocal High-Content Imaging System
The ImageXpress Micro Confocal High-Content Imaging System provides improved quantification for live or fixed cell assays. This versatile imaging s…
-
Product Brochure
MetaXpress High-Content Image Acquisition and Analysis Software
Capture high-resolution images, recognize and segment objects, calculate parameters, and then translate your information into meaningful data. At M…
-
Product Brochure
ImageXpress Micro High-Content Imaging Systems
Our high-content imaging family of products provides the ultimate flexibility and performance to help researchers and screeners perform tailored as…
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Product Brochure
3D Image Analysis Module
Complex assays and three-dimensional cell models better represent tissue biology and cell interactions, making them more relevant for many toxicity…
Application Note
Assessment of drug effects on cardiomyocyte physiology using human…
Cell models are becoming more
complex in order to better mimic in vivo
microenvironments and provide greater
predictivity for…-
Application Note
High-content assay for morphological characterization of 3D neuronal…
Development of more complex,
biologically relevant, and predictive cellbased
assays for compound screening
is a primary… -
Application Note
Automating the generation and analysis of 3D cell cultures in…
Researchers are turning to three-dimensional (3D) cell culture as a way to increase the biological relevance of their disease
models and… -
Application Note
Automation of 3D spheroid cultures in ultra-low attachment plates
We have previously described the automated plating, treatment, and analysis of 3D spheroids formed in hanging drop
plates (see Automated 3D… -
Application Note
Multi-parameter imaging assay for measuring toxicity in a tumor model
There is an increasing interest in using
three-dimensional (3D) spheroids for
modeling cancer and tissue biology
to accelerate… -
Application Note
3D analysis and morphometric characterization of compound effects on…
Cellular transformation/tumorigenicity assays using cultures of cells in semi-solid media (soft agar or Matrigel) has been well established for…
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Application Note
High-content 3D toxicity assay using iPSC-derived hepatocyte spheroids
There is increasing interest in exploring the
use of three-dimensional (3D) spheroids
for modeling developmental and tissue
… -
Application Note
High-Throughput Confocal Imaging of Spheroids for Screening Cancer…
In recent years, there has been significant progress in development of in vitro aggregates of tumor cells for use as models for in vivo tissue…
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Application Note
Live cell kinetics assay utilizing the ImageXpress Micro System
The ImageXpress® Micro Confocal/ XLS Widefield High-Content Imaging System from Molecular Devices includes optional Fluidics and Environmental…
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Application Note
Assaying cardiotoxicity with ImageXpress high-content screening…
The discovery and development of novel drugs is a difficult and expensive process due to lack of tools and techniques to accurately reproduce the…
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Application Note
Visualizing subcellular vesicles to quantitate autophagy in neuronal…
Autophagy is an intracellular catabolic process that sequesters and degrades proteins and organelles that have either been recognized as faulty or…
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Application Note
Increase sensitivity in no-wash assays using confocal imaging
Screening of hybridoma supernatants for antibodies directed against cell-surface antigens is an important step in the discovery and development of…
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Application Note
High-throughput imaging assays using zebrafish, a model organism for…
Recently, zebrafish-based screening has gained favor as an alternative to mammalian screening due to cost, throughput and reduced ethical concerns.…
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Application Note
Apoptosis detection using EarlyTox Caspase-3/7-D NucView 488 Assay…
Apoptosis is an important mechanism signaling programmed death of cells in normal processes such as embryonic development, as well as in diseases…
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Application Note
High-content screening of neuronal toxicity using iPSC-derived human…
The nervous system is sensitive to the toxic effects of many chemical compounds, environmental agents and certain naturally occurring substances.…
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Application Note
Intelligent time-lapse imaging to enhance live cell assay development
The ability to monitor responses in living cells over a specific period of time offers cell biologists several key advantages for assay development.…
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Application Note
Multiplexed high content hepatotoxicity assays using iPSC-derived…
Drug-induced hepatotoxicity is an important cause for liver injury and acute liver failure. Thus highly predictive assays for safety and efficacy…
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Application Note
Monitoring BNP Expression and Cell Size to Determine Hypertrophic…
Cardiac hypertrophy is a condition associated with many heart diseases such as myocardial infarction, ischemia, hypertension, valvular dysfunctions,…
Data Sheet
NEW ImageXpress Micro Confocal High-Content Imaging System
The new ImageXpress® Micro Confocal High-Content Imaging System enables you to expand the boundaries of your research with the ultimate combination…
eBook
Acquire and analyze 3D images like a pro
High complexity cellular models such as three-dimensional (3D) spheroids better mimic in vivo environments compared to simpler two-dimensional (2D)…
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eBook
Advance Detection of Cytotoxicity
A wide range of solutions for predicting cytotoxicity earlier in your drug discovery process.
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Product Brochure
Molecular Devices Imaging
Mimetas uses their OrganoPlate® to develop disease, toxicology, and transport models for research, development and drug screening. For development…
Scientific Poster
High-Throughput Assays for Characterizing Viability and Morphology of…
Three-dimensional (3D) in vitro models span the gap between two-dimensional cell cultures and whole-animal systems. By mimicking features of the in…
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Scientific Poster
Phenotypic Assessment of Toxicity Using a Human Hepatocyte Co-Culture…
Development of predictive in vitro assays for early toxicity evaluation is extremely important for improving the drug development process and reduc…
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Scientific Poster
Novel High Content Stem Cell-based Assays for Screening
The biopharma industry is continuing to adapt more cell-based assays for primary and secondary screening because of higher biological relevance and…
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Scientific Poster
High-Content Assay for Morphological Characterization of 3D Neuronal…
The absence of physiologically relevant in vitro models of the nervous system is an important limitation in using 3D cultures for assay development…
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Scientific Poster
Phenotypic Characterization of Compound Effects on iPSC-derived…
Explore PDF & learn the use of fast kinetic fluorescence and 3D image analysis for Phenotypic characterization of compound effects on iPSC-deri…
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Scientific Poster
In Vitro Assessment of Drug Effects on Human iPSC-Derived Cardiac…
for modeling developmental and tissue biology with the goal of accelerating translational research. Such 3D models can provide different perspectiv…
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Scientific Poster
Increase Sensitivity with Confocal Acquisition in a High-Throughput…
Learn how to improve sensitivity of DNA damage detection & genotoxicity sensitivity with confocal acquisition to detect nuclear punctae in a hi…
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Scientific Poster
Screening Cell Cycle Inhibitors using Automated High-Content Imaging
Monitoring treatment effects on the cell cycle is particularly relevant to progressing oncology research and drug discovery. For instance, compound…
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Scientific Poster
High-Content Assay for Morphological Characterization of Neuronal…
Development of more complex, biologically relevant, and predictive cell-based assays for compound screening is one of the main challenges in drug d…
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Scientific Poster
Predictive Assays for High Throughput Assessment of Cardiac Toxicity…
Read more about cell based assays for measuring the impact of pharmacological compounds on the rate of beating cardiomyocytes with different assay…
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Scientific Poster
Morphometric Characterization of Cancer Spheroid Cultures Using…
There is an emerging interest in using three-dimensional (3D) organoid cultures for modeling tissue biology and cancer. Development of higher throu…
Videos
Morphological Characterization of 3D Neuronal Networks in a Microfluidic Platform
3D Imaging of Cancer Spheroids
High-Content Screening for Identifying miRNAs
Identification of Selective Inhibitors of the STAT3 Signaling Pathway
Oliver Kepp and Jayne Hesley - Hallmarks of Cancer - Detect and Quantify Cell Death Signatures with High Content Imaging
Multidimensional High-Throughput Imaging with the New ImageXpress Micro Confocal System
Pushing the Boundaries of High Content Screening
Preparing Assays for Genome-wide RNAi Screens Using High Content Microscopy
Multiplexed High Content Hepatoxicity Assays Using iPSC-Derived Hepatocytes
High Content Imaging Analysis of Cell Sheet Morphogenesis Utilizing in Virto Tissue Models
Simple and Flexible High Content Imaging Enabling Quantitation of Complex Biological Events
Contemporary Automation and High Content Imaging Tools for Screening Stem Cell-Derived Cardiomyocytes
Implement High-Throughput 3D Image Analysis for Samples from Subcellular Structures to Spheroids
Live Cell Imaging to Investigate the Regulation of Cell Division Timing
Using High-throughput RNA Screening to Identify Host Factors That Impact Viral Infection
Application of HCA Tools for Antibody Drug Discovery
Setting up 3D Spheroid Assays Using High-Content Imaging
Physiologically-Relevant Tissue Models Using a High-Throughput Organ-on-a-Chip Platform
Emerging Induced Pluripotent Stem Cell Applications in Drug Discovery
Related Products & Services of ImageXpress Micro Confocal High-Content Imaging System
Featured Applications
3D Cell Imaging and Analysis
Three-dimensional (3D) cell models are physiologically relevant and more closely represent tissue…
Read More
3D Gel Matrix Assays
The development and integration of three-dimensional (3D) assay models are becoming popular to…
Read More
Neurite Outgrowth / Neurite Tracing
Neurons create connections via extensions of their cellular body called processes. This biological…
Read More
Organ-on-a-Chip Assays
Emulating organ physiology by co-culturing cells in a supportive 3D matrix and using microfluidic…
Read More
Spheroid Assays
Three-dimensional (3D) cells cultured into spheroids provide a more complete and physiologically…
Read More
Toxicity Screening
Screening for off-target or toxic effects is very important during the development of new drugs and…
Read MoreCustomer Breakthrough
SUCCESS STORY
MIMETAS uses the ImageXpress Confocal system to develop tissues models for their OrganoPlates®
A unique 3D organ-on-a-chip platform
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We are ready to help you solve your tough research challenges. Our proven solutions and highly qualified teams across the globe can help advance your next big discovery.