ImageXpress Micro Confocal High-Content Imaging System
Unique confocal imaging solution capable of imaging more than a million wells a week
High-content imaging solution with proprietary spinning disc confocal
The ImageXpress® Confocal system is a high-content solution that can switch between widefield and confocal imaging of fixed and live cells. It can capture high quality images of whole organisms, thick tissues, 2D and 3D models, and cellular or intracellular events. The spinning disc confocal and sCMOS camera enable imaging of fast and rare events like cardiac cell beating and stem cell differentiation. With the MetaXpress software, the system enables many confocal imaging applications from 3D assay development to screening.
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Acquire higher quality images
Capture excellent contrast, high resolution images with our proprietary AgileOptix™ spinning disc confocal technology, wide field of view, and bright light source.
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Customize image acquisition and analysis
Take ultimate control over acquisition and analysis parameters, which enables many applications from 3D structure analysis to targeted imaging of specific objects within an organism or cell populations.
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Analyze more data in less time
MetaXpress® PowerCore™ software accelerates analysis speed in a high-throughput environment. The software distributes image processing jobs to a multi-CPU environment.
ImageXpress Micro Confocal Video
Features
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Wide dynamic range
Quantify low and high intensity signals in a single image with >3 log dynamic range intensity detection.
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Exclusive AgileOptix spinning disc confocal
The technology provides increased sensitivity with custom optics, high-powered, solid state light engines, and sCMOS technology. Swappable disc geometries provide flexibility between speed and resolution.
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Wide field of view
Wide field of view enables whole-well confocal imaging and eliminates missed targets.
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Optional on-board robotic fluidics
For assays that involve compound addition, well washing, and media exchange, optional on-board robotic fluidics are available.
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Accurate 3D measurements
MetaXpress 3D analysis module is optimized for confocal imaging, enabling 3D measurements of volume and distance.
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Multiple imaging modes
The system offers phase contrast and brightfield label-free imaging, fluorescence, widefield, colorimetric, and confocal imaging.
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eBook
Cellular Imaging Insights
Gain insights and expedite studies for 2D and 3D cellular structures using automated cellular imaging.
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Infographic
3D Imaging Advantage
Learn about the advantage and the technology behind 3D cellular image acquisition and analysis.
Applications of ImageXpress Micro Confocal High-Content Imaging System
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Organ-on-a-Chip Assays
Emulating organ physiology by co-culturing cells in a supportive 3D matrix and using microfluidic channels to perfuse nutrients or compounds over the resulting cellular structures, is rapidly gaining popularity as a biologically relevant screening model for new drugs or toxicity. The ImageXpress system provides a turnkey solution for both 2D or 3D applications and can accommodate many different types of slide and plate formats.
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Neurite Outgrowth / Neurite Tracing
Neurons create connections via extensions of their cellular body called processes. This biological phenomenon is referred to as neurite outgrowth. Understanding the signaling mechanisms driving neurite outgrowth provides valuable insight into neurotoxic responses, compound screening, and for interpreting factors influencing neural regeneration. Using the ImageXpress Micro system in combination with MetaXpress Image Analysis Software automated neurite outgrowth imaging and analysis is possible for slide or microplate-based cellular assays.
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Spheroid Assays
Three-dimensional (3D) cells cultured into spheroids provide a more complete and physiologically predictive model especially for cancer research. Acquiring measurements from the larger structure involves acquiring images from different depths within the body of the spheroid and analyzing them in 3D or collapsing into a single 2D stack before analysis. The ImageXpress Micro system and MetaXpress software are designed to make acquisition and analysis of 3D spheroids fast and accurate.
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3D Cell Imaging and Analysis
Three-dimensional (3D) cell models are physiologically relevant and more closely represent tissue microenvironments, cell-to-cell interactions, and biological processes that occur in vivo. Now you can generate more predictive data by incorporating technologies like the ImageXpress system with the integrated 3D Analysis Module in MetaXpress® software. This single interface will enable you to meet 3D acquisition and analysis challenges without compromise to throughput or data quality, giving you confidence in your discoveries.
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3D Gel Matrix Assays
The development and integration of three-dimensional (3D) assay models are becoming popular to drive translational biology. Our ImageXpress system allows superior visualization of thick samples by minimizing background fluorescence and increasing sharpness, resulting in accurate image segmentation. Increase the biological relevance of your screening assays with a seamless integration between acquisition and analysis of cells in a 3D space to yield volume, intensity, and distance measurements.
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Toxicity Screening
Screening for off-target or toxic effects is very important during the development of new drugs and for the extension of the therapeutic potential of existing molecules. ImageXpress systems are fully integrated hardware and software platforms for automated acquisition and analysis of images for high-throughput cell-based cytotoxicity testing. Configured with optional environmental control, living cell responses or kinetic reactions can be monitored in real time for several days.
Specifications & Options of ImageXpress Micro Confocal High-Content Imaging System
Resources of ImageXpress Micro Confocal High-Content Imaging System
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eBook
Cellular Imaging Insights
Gain insights and expedite studies for 2D and 3D cellular structures using automated cellular imaging.
-
Infographic
3D Imaging Advantage
Learn about the advantage and the technology behind 3D cellular image acquisition and analysis.
Product Brochure
ImageXpress Micro Confocal high-content imaging system
The ImageXpress Micro Confocal High-Content Imaging System provides improved quantification for live or fixed cell assays. This versatile imaging system features a unique confocal techn…
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Product Brochure
MetaXpress High-Content Image Acquisition and Analysis Software
Capture high-resolution images, recognize and segment objects, calculate parameters, and then translate your information into meaningful data. At Molecular Devices, we’re inspired by yo…
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Product Brochure
ImageXpress Micro High-Content Imaging Systems
Our high-content imaging family of products provides the ultimate flexibility and performance to help researchers and screeners perform tailored assays and shorten time to result. From…
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Product Brochure
3D Image Analysis Module
Complex assays and three-dimensional cell models better represent tissue biology and cell interactions, making them more relevant for many toxicity and drug screening assays. The abilit…
Scientific Poster
Neurotoxicity profiling using 3D human iPSC-derived neural spheroids
Test compound effects and screen for neurotoxic chemicals using 3D neural spheroids.
Application Note
Counting cells with the Transmitted Light Analysis Module in MetaXpress
Label-free cellular assays are required for a multitude of biological applications that monitor the cell number, proliferation, health, confluency, and cytotoxicity. In this…
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Application Note
Analyze experimental results using curve fitting with MetaXpress 6.5 software
The ability to annotate your plate, plot your data into a graph, and produce a variety of curves and readouts including IC50 values and benchmark dose or concentration for your…
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Application Note
Assessment of drug effects on cardiomyocyte physiology using human iPSC-derived cardiac spheroids
Cell models are becoming more complex in order to better mimic in vivo microenvironments and provide greater predictivity for compound efficacy and toxicity. There is an increasing…
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Application Note
High-content assay for morphological characterization of 3D neuronal networks in a microfluidic platform
Establishment of physiologically-relevant in vitro models is crucial to further understanding of the mechanisms of neurological diseases as well as targeted drug development. While…
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Application Note
Automating the generation and analysis of 3D cell cultures in Matrigel®
Researchers are turning to three-dimensional (3D) cell culture as a way to increase the biological relevance of their disease models and predictive value of drug studies. These 3D…
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Application Note
Automation of 3D spheroid cultures in ultra-low attachment plates
We have previously described the automated plating, treatment, and analysis of 3D spheroids formed in hanging drop
plates (see Automated 3D Cell Culture and Screening by Imaging… -
Application Note
Multi-parameter imaging assay for measuring toxicity in a tumor model
There is an increasing interest in using three-dimensional (3D) spheroids for modeling cancer and tissue biology to accelerate translational research. The goal of this study was to…
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Application Note
3D analysis and morphometric characterization of compound effects on cancer spheroid cultures
Cellular transformation/tumorigenicity assays using cultures of cells in semi-solid media (soft agar or Matrigel) has been well established for cancer research1,2,5. The assay requires…
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Application Note
High-content 3D toxicity assay using iPSC-derived hepatocyte spheroids
There is increasing interest in exploring the use of three-dimensional (3D) spheroids for modeling developmental and tissue biology with the goal of accelerating translational research…
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Application Note
High-Throughput Confocal Imaging of Spheroids for Screening Cancer Therapeutics
In recent years, there has been significant progress in development of in vitro aggregates of tumor cells for use as models for in vivo tissue environments. When seeded into a well of…
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Application Note
Live cell kinetics assay utilizing the ImageXpress Micro System
The ImageXpress® Micro Confocal/ XLS Widefield High-Content Imaging System from Molecular Devices includes optional Fluidics and Environmental Control modules, enabling single-channel…
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Application Note
Assaying cardiotoxicity with ImageXpress high-content screening systems
The discovery and development of novel drugs is a difficult and expensive process due to lack of tools and techniques to accurately reproduce the human physiological response in the…
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Application Note
Visualizing subcellular vesicles to quantitate autophagy in neuronal cells
Autophagy is an intracellular catabolic process that sequesters and degrades proteins and organelles that have either been recognized as faulty or are simply no longer needed by the…
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Application Note
Increase sensitivity in no-wash assays using confocal imaging
Screening of hybridoma supernatants for antibodies directed against cell-surface antigens is an important step in the discovery and development of antibodies for vaccines or…
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Application Note
High-throughput imaging assays using zebrafish, a model organism for human disease
Recently, zebrafish-based screening has gained favor as an alternative to mammalian screening due to cost, throughput and reduced ethical concerns. Zebrafish are a useful model for…
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Application Note
Apoptosis detection using EarlyTox Caspase-3/7-D NucView 488 Assay Kit on ImageXpress Micro systems
Apoptosis is an important mechanism signaling programmed death of cells in normal processes such as embryonic development, as well as in diseases including cancer and neurodegenerative…
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Application Note
High-content screening of neuronal toxicity using iPSC-derived human neurons
The nervous system is sensitive to the toxic effects of many chemical compounds, environmental agents and certain naturally occurring substances. Neurotoxicity can cause temporary or…
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Application Note
Intelligent time-lapse imaging to enhance live cell assay development
The ability to monitor responses in living cells over a specific period of time offers cell biologists several key advantages for assay development. For routine cellbased screening,…
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Application Note
Multiplexed high content hepatotoxicity assays using iPSC-derived hepatocytes
Drug-induced hepatotoxicity is an important cause for liver injury and acute liver failure. Thus highly predictive assays for safety and efficacy testing are crucial for improving drug…
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Application Note
Monitoring BNP Expression and Cell Size to Determine Hypertrophic Response in Human Cardiomyocytes
Cardiac hypertrophy is a condition associated with many heart diseases such as myocardial infarction, ischemia, hypertension, valvular dysfunctions, and is also observed as a toxic…
Data Sheet
NEW ImageXpress Micro Confocal High-Content Imaging System
The new ImageXpress® Micro Confocal High-Content Imaging System enables you to expand the boundaries of your research with the ultimate combination of speed, sensitivity and flexibility…
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eBook
Quantitate Neuron Potential
Gain valuable insights into neurobiology, from evaluation of ion channels to analysis of 3D neuron organoids.
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eBook
Acquire and analyze 3D images like a pro
High complexity cellular models such as three-dimensional (3D) spheroids better mimic in vivo environments compared to simpler two-dimensional (2D) models. While the development of quan…
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Product Brochure
Imaging Family Brochure
Learn about our imaging family and which solution is best suited to answer your biological questions.
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Scientific Poster
High-Throughput Assays for Characterizing Viability and Morphology of 3D Cancer Spheroid Cultures
Three-dimensional (3D) in vitro models span the gap between two-dimensional cell cultures and whole-animal systems. By mimicking features of the in vivo environment and taking advantage…
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Scientific Poster
Phenotypic Assessment of Toxicity Using a Human Hepatocyte Co-Culture Model
Development of predictive in vitro assays for early toxicity evaluation is extremely important for improving the drug development process and reducing drug attrition rates during clinic…
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Scientific Poster
Novel High Content Stem Cell-based Assays for Screening
The biopharma industry is continuing to adapt more cell-based assays for primary and secondary screening because of higher biological relevance and increased value of information.
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Scientific Poster
High-Content Assay for Morphological Characterization of 3D Neuronal Networks in a Microfluidic Platform
The absence of physiologically relevant in vitro models of the nervous system is an important limitation in using 3D cultures for assay development applicable for neurodegenerative dise…
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Scientific Poster
Phenotypic Characterization of Compound Effects on iPSC-derived Cardiac & Liver Spheroids
Explore PDF & learn the use of fast kinetic fluorescence and 3D image analysis for Phenotypic characterization of compound effects on iPSC-derived Cardiac and Liver Spheroids.
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Scientific Poster
In Vitro Assessment of Drug Effects on Human iPSC-Derived Cardiac Spheroid Cultures
for modeling developmental and tissue biology with the goal of accelerating translational research. Such 3D models can provide different perspectives from traditional 2D cultures on the…
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Scientific Poster
Increase Sensitivity with Confocal Acquisition in a High-Throughput Imaging Assay for Detecting DNA Damage and Genotoxicity
Learn how to improve sensitivity of DNA damage detection & genotoxicity sensitivity with confocal acquisition to detect nuclear punctae in a high throughput imaging assay.
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Scientific Poster
Screening Cell Cycle Inhibitors using Automated High-Content Imaging
Monitoring treatment effects on the cell cycle is particularly relevant to progressing oncology research and drug discovery. For instance, compounds known to inhibit mitosis are often u…
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Scientific Poster
High-Content Assay for Morphological Characterization of Neuronal Development in 3D Matrix Using Human iPSC-Derived Neuronal Cultures
Development of more complex, biologically relevant, and predictive cell-based assays for compound screening is one of the main challenges in drug discovery. There is an increasing inter…
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Scientific Poster
Predictive Assays for High Throughput Assessment of Cardiac Toxicity and Drug Safety
Read more about cell based assays for measuring the impact of pharmacological compounds on the rate of beating cardiomyocytes with different assay platforms.
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Scientific Poster
Morphometric Characterization of Cancer Spheroid Cultures Using Confocal Imaging and 3D Image Analysis
There is an emerging interest in using three-dimensional (3D) organoid cultures for modeling tissue biology and cancer. Development of higher throughput assays to quantify phenotypic ch…
Videos and Demos
Morphological Characterization of 3D Neuronal Networks in a Microfluidic Platform
3D Imaging of Cancer Spheroids
High-Content Screening for Identifying miRNAs
Identification of Selective Inhibitors of the STAT3 Signaling Pathway
Oliver Kepp and Jayne Hesley - Hallmarks of Cancer - Detect and Quantify Cell Death Signatures with High Content Imaging
Multidimensional High-Throughput Imaging with the New ImageXpress Micro Confocal System
Pushing the Boundaries of High Content Screening
Preparing Assays for Genome-wide RNAi Screens Using High Content Microscopy
Multiplexed High Content Hepatoxicity Assays Using iPSC-Derived Hepatocytes
High Content Imaging Analysis of Cell Sheet Morphogenesis Utilizing in Virto Tissue Models
Simple and Flexible High Content Imaging Enabling Quantitation of Complex Biological Events
Contemporary Automation and High Content Imaging Tools for Screening Stem Cell-Derived Cardiomyocytes
Implement High-Throughput 3D Image Analysis for Samples from Subcellular Structures to Spheroids
Live Cell Imaging to Investigate the Regulation of Cell Division Timing
Using High-throughput RNA Screening to Identify Host Factors That Impact Viral Infection
Application of HCA Tools for Antibody Drug Discovery
Setting up 3D Spheroid Assays Using High-Content Imaging
Physiologically-Relevant Tissue Models Using a High-Throughput Organ-on-a-Chip Platform
Emerging Induced Pluripotent Stem Cell Applications in Drug Discovery
StemoniX microBrain 3D Assay Ready Plates for HTS
Related Products & Services of ImageXpress Micro Confocal High-Content Imaging System
Featured Applications
3D Cell Imaging and Analysis
Three-dimensional (3D) cell models are physiologically relevant and more closely represent tissue…
Read More
3D Gel Matrix Assays
The development and integration of three-dimensional (3D) assay models are becoming popular to…
Read More
Neurite Outgrowth / Neurite Tracing
Neurons create connections via extensions of their cellular body called processes. This biological…
Read More
Organ-on-a-Chip Assays
Emulating organ physiology by co-culturing cells in a supportive 3D matrix and using microfluidic…
Read More
Spheroid Assays
Three-dimensional (3D) cells cultured into spheroids provide a more complete and physiologically…
Read More
Toxicity Screening
Screening for off-target or toxic effects is very important during the development of new drugs and…
Read MoreCustomer Breakthrough
SUCCESS STORY
HCS Pharma uses ImageXpress Micro Confocal Systems for phenotypic screening of physiologically relevant 3D cell models
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