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ImageXpress Micro Confocal High-Content Imaging System

ImageXpress Micro Confocal High-Content Imaging System

Unique confocal imaging solution capable of imaging more than a million wells a week

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High-content confocal imaging solution with water objective options

The ImageXpress® Micro Confocal system is a high-content solution that can switch between widefield and confocal imaging of fixed and live cells. It can capture high quality images of whole organisms, thick tissues, 2D and 3D models, and cellular or intracellular events. The spinning disk confocal and sCMOS camera enable imaging of fast and rare events like cardiac cell beating and stem cell differentiation. With MetaXpress software and flexible options like water immersion objectives to choose from, the system enables many confocal imaging applications from 3D assay development to screening.

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Acquire higher quality images

Capture excellent contrast, high resolution images with our proprietary AgileOptix™ spinning disk confocal technology, wide field of view, and bright light source.

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Customize image acquisition and analysis

Take ultimate control over acquisition and analysis parameters, which enables many applications from 3D structure analysis to target imaging of specific objects within an organism or cell populations. Run more applications with standard options like water immersion objectives, environmental control, or any of our high-performance customizations.

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Analyze more data in less time

MetaXpress® PowerCore™ software accelerates analysis speed in a high-throughput environment. The software distributes image processing jobs to a multi-CPU environment.

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Features

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Wide dynamic range

Quantify low and high intensity signals in a single image with >3 log dynamic range intensity detection.

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Exclusive AgileOptix spinning disk confocal

The technology provides increased sensitivity with specially designed optics, high-powered, solid state light engines, and sCMOS sensor. Swappable disc geometries provide flexibility between speed and resolution.

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Wide field of view

Wide field of view enables whole-well confocal imaging and eliminates missed targets.

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Optional on-board robotic fluidics

For assays that involve compound addition, well washing, and media exchange, optional on-board robotic fluidics are available.

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Accurate 3D measurements

MetaXpress 3D analysis module is optimized for confocal imaging, enabling 3D measurements of volume and distance.

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Multiple imaging modes

The system offers phase contrast and brightfield label-free imaging, fluorescence, widefield, colorimetric, and confocal imaging, as well as, water immersion imaging as a standard option.

AgileOptix™ technology

Our proprietary AgileOptix technology enables the ImageXpress Micro Confocal system to deliver the sensitivity and throughput needed for demanding applications. AgileOptix is the combination of a powerful solid state, light engine, specially designed optics, scientific CMOS sensor, and the ability to change disk geometries.

AgileOptix Technology for ImageXpress Micro Confocal

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Introducing the MetaXpress 3D Analysis Toolkit

MetaXpress high-content image aquisition and analysis software

  • Meet high throughput requirements with a scalable, streamlined workflow
  • Adapt your analysis tools to tackle your toughest problems, including 3D analysis
  • Schedule automatic data transfer between third-party hardware sources and secure database
  • Set up hundreds of routinely used HCS assays using MetaXpress software modules

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Data and images were acquired during development using customer samples. Results may vary. Highlighted features’ price, time to deliver, and specifications will vary based on mutually agreed technical requirements. Solution requirements may cause adjustment to standard performance.

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Customer Breakthrough

Visikol used ImageXpress Micro Confocal High-Content Imaging System

SUCCESS STORY

Visikol team develops 3D cell culture models to simulate the NASH and NAFLD disease progression process using ImageXpress Micro Confocal High-Content Imaging System and MetaXpress software

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How can we help advance your next big discovery?

Our highly-qualified teams are on the frontlines with our customers, conducting remote or on-site product demonstrations, webinars, and more to help you solve your tough research challenges. How can we help you today?

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Expand your research using flexible, high-performance imaging solutions

Molecular Devices provides flexible options for the ImageXpress Micro Confocal High-Content Imaging System to meet your research needs and to easily capture images from different sample formats, including hanging drops and in round or flat bottom plates, for monitoring cell health kinetics under environmental control, and more. With over 30+ years of imaging expertise, we can help you select the right options to ensure the best images for your assay.

Standard hardware options

Water immersion objectives

Water immersion objectives

20X, 40X, and 60X water immersion objectives improve the geometric accuracy during acquisition and reduce light refraction for brighter intensity at lower exposure times.

Phrase Contrast

Transmitted light tower

Our transmitted light tower enables acquisition of high contrast images for unstained cells which can be easily viewed or separated from background.

urnkey, high-throughput long term kinetics

Environmental Control

Environmental control maintains temperature and humidity levels while minimizing evaporation for multi-day, live cell, time-lapse imaging.

Robotic Automation

On-board robotic fluidics

Integrated fluidics automates assay workflows which require compound addition, well washing, and media exchange.

Customization options

Molecular Devices can successfully tailor the ImageXpress Micro Confocal High-Content Imaging System to include customized software and hardware including the features described below, as well as integration of other lab components such as incubators, liquid handlers, and robotics for a fully automated workcell. With over 30 years of experience in the life science industry, you can count on us to deliver quality products and provide worldwide support.

Sale is subject to our Custom Product Purchase Terms available at www.moleculardevices.com/custom-products-purchase-terms

High-Intensity lasers

High-Intensity lasers

Expand experiment capabilities with 5- or 7-channel high-intensity lasers.

Automatic Pipettor

Real-time dose response

Automatic pipettor enables compound addition while simultaneously live streaming at >100 frames per second.

Confocal Disk Module

Deep tissue penetrating confocal disk module

The deep tissue penetrating, confocal disk module reduces crosstalk to improve out-of-focus light suppression and penetrate deeper into tissue.

urnkey, high-throughput long term kinetics

Turnkey, High-throughput long term kinetics

Schedule and image multiple plates over long periods of time while keeping consistent temperature, O2(Hypoxia), CO2, and humidity conditions. Expand live cell walk-away capacity to 200+ plates.

Robotic Automation

Scale up robotic automation

Increase throughput, eliminate human errors, maintain sterility, and achieve consistent sample handling. Modular automation design—components can be added in modules and are upgradeable.

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High Intensity Lasers

High-intensity Lasers

High output laser excitation can reduce exposure times by up to 75%.† The laser light source is available as either a 5-channel or 7-channel light source with outputs of 400 —1,000 mW/channel. The 7-channel laser light source Includes near IR and is ideal for customers with increased multiplexing requirements.

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Standard
Laser
Standard Intensity Image
High-Intensity Lasers Image
Images taken at the same exposure.

Confocal Disk Module

Deep Tissue Penetrating, Confocal Disk Module

Specialized deep tissue penetrating, confocal disk module, combined with a laser light source, improves light penetrance for deeper tissue penetration, resulting in sharper images with improved resolution when imaging thick tissue samples†.

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Standard spinning disk
Deep tissue penetrating, confocal disk module
Standard Spinning Disc
Deep Tissue Penetrating with Confocal Disk
Images taken at the same exposure.
†Data and images were acquired during development using customer samples. Results may vary. Highlighted features’ price, time to deliver, and specifications will vary based on mutually agreed technical requirements. Solution requirements may cause adjustment to standard performance.

Applications of ImageXpress Micro Confocal High-Content Imaging System

Specifications & Options of ImageXpress Micro Confocal High-Content Imaging System

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Resources of ImageXpress Micro Confocal High-Content Imaging System

Number of Citations*: 2,470

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