Automated fluorescence imaging that’s easier than digital microscopy
The ImageXpress® Pico Automated Cell Imaging System combines high-resolution imaging and powerful analysis, with a streamlined workflow. It includes CellReporterXpress® software for acquisition and analysis, and features a comprehensive portfolio of preconfigured protocols. The automated setup of analysis parameters shortens the learning curve, so you can start running experiments quickly. If you’re in the market for fluorescence imaging or digital microscopy, the ease and affordability of an automated imager is now within reach.
Get started quickly
With the approachable, icon-driven CellReporterXpress software, everyone can use the ImageXpress Pico system with minimal training to capture and analyze your first image.
Do more than cell counting
Expand your assays beyond cell counting with preconfigured templates for many commonly used cell imaging and analysis protocols such as apoptosis and detection of mitochondria.
Alleviate the hassle of going to the core lab to run your samples. The system’s lab-friendly price affords the convenience of automated imaging and analysis on your lab bench.
Multiple imaging modes
The ImageXpress Pico system provides user- and software-selectable objectives ranging from 4X to 63X, fluorescence imaging, live cell imaging, and brightfield imaging modes.
Predefined cell imaging protocols
The system offers preconfigured cell imaging protocols ranging from simple cell count to sophisticated neurite tracing analysis, removing the guesswork from optimizing parameters.
Plate-to-individual cell view
Data can be visualized at multiple levels from plate overviews to individual cells. Images are clickable to locate cells that match specific criteria.
Integrated data visualization tools
Liberate your lab from tedious digital microscopy, the software transforms images into data on the fly. Scatter plots, videos, and more can be generated automatically with just a few clicks.
Advanced slide scanning workflow
Whole slide scanning, for the determination of regions of interest, is quick and easy. Acquires higher resolution scans of only the select regions, saving time and data storage.
Temperature control up to 40◦C is standard on every ImageXpress Pico system, making live cell imaging a possibility.
Applications of ImageXpress Pico Automated Cell Imaging System
Neurite Outgrowth / Neurite Tracing
Neurons create connections via extensions of their cellular body called processes. This biological phenomenon is referred to as neurite outgrowth. Understanding the signaling mechanisms driving neurite outgrowth provides valuable insight into neurotoxic responses, compound screening, and for interpreting factors influencing neural regeneration. Using the ImageXpress Micro system in combination with MetaXpress Image Analysis Software automated neurite outgrowth imaging and analysis is possible for slide or microplate-based cellular assays.
Apoptosis is a process of programmed cell death important to a number of biological processes including embryonic development and normal tissue maintenance. Disruption in the regulation of apoptosis has been implicated in various diseases including cancer. Biochemical events lead to characteristic changes in cell morphology such as cell shrinkage, nuclear fragmentation, chromatin condensation, and mRNA decay, and ultimately cell death. Apoptosis can be initiated via the intrinsic or extrinsic pathways, and both pathways induce cell death by activating caspase enzymes
Cell counting is fundamental and critical to numerous biological experiments. Assays such as drug compound toxicity, cell proliferation, and inhibition of cell division have a need to assess the number or density of cells in a well. Automated imaging can greatly speed up the cell counting process while reducing manual labor and human errors. Cells can be counted using a variety of methods, such as label-free cell counting under transmitted light or detection of nuclear dye with fluorescent imaging.
Resources of ImageXpress Pico Automated Cell Imaging System
Automate complex cell-based assays with multi-parametric readouts while maintaining high data quality and precision.
There is a great need to automate complex cell-based assays with multi-parametric read-outs while maintaining high data quality and precision. A compact, automated imaging system was us…
Evaluate compound-specific effects on neurite outgrowth using automated imaging
Detect and quantify compound effects on the process of autophagy on the ImageXpress Pico system. The PC12 human neuroblastoma cell line was used as a model for assay development.
Automated cellular imaging is an efficient method for analyzing compound effects on cell phenotypes including morphology, viability, and marker expression.
Evaluation of mitochondrial integrity and mitochondria membrane potential using automated cell imaging and analysis
Mitochondrial function, a key indicator of cell health, can be assessed by monitoring changes in mitochondrial membrane potential (MMP)1,2.
Live/dead assays are utilized in a wide variety of research applications including investigation of cytotoxic effects of various compounds, treatments, or changes in gene expression.
Apoptosis is a process of programmed cell death that occurs in multicellular organisms.1,2 Biochemical events lead to characteristic changes in cell morphology and cell death.
Videos and Demos
Setting up acquisition and analysis on the ImageXpress Pico
Transmitted light cell scoring on the ImageXpress Pico
Reviewing completed experiments on the ImageXpress Pico
ImageXpress Pico Automated Cell Imaging System
Related Products & Services of ImageXpress Pico Automated Cell Imaging System
Apoptosis is a process of programmed cell death important to a number of biological processes…Read More
Cell counting is fundamental and critical to numerous biological experiments. Assays such as drug…Read More
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