Digital microscopy with automated brightfield and fluorescence imaging

The ImageXpress® Pico Automated Cell Imaging System is more than a digital microscope, combining high-resolution imaging with powerful analysis. Whether running fluorescence imaging or brightfield assays, the automated imager features a comprehensive portfolio of preconfigured protocols for cell-based assays to shorten the learning curve, so you can start running experiments quickly.

  • Get started quickly

    Get started quickly

    Streamline digital microscopy with the icon-driven, user-friendly CellReporterXpress™ software to minimize setup and shorten training time.

  • Do more than cell counting

    Do more than cell counting

    Expand your assay capabilities with over 25 preconfigured templates optimized for cell-based experiments including apoptosis, mitochondrial evaluation, 3D cell models, live cell/time lapse, and neurite tracing.

  • Cost Effective

    Image economically

    Alleviate the hassle of going to the core lab to run your samples. The system’s lab-friendly price affords the convenience of automated digital microscopy in every lab.

ImageXpress Pico Automated Cell Imaging System-Interactive Demo

Features

  • Multiple imaging modes

    The ImageXpress Pico system offers objectives ranging from 4x to 63x and can operate in colorimetric, brightfield, or fluorescence imaging modes.

  • Preconfigured analysis protocols

    Preconfigured analysis protocols ranging from cell counting to sophisticated neurite tracing analysis removes the guess work from optimizing parameters. 

  • Plate-to-individual cell view

    Data can be visualized at multiple levels from plate overview to individual cells. The cell click-to-find tool also makes it easy to automatically locate cells that match specific criteria. 

  • Z-stack acquisition

    Z-stack acquisition enables the generation of sharper images and more accurate segmentation. A series of images acquired at different focal points captures more details than with an individual slice.

  • Advanced slide-imaging workflow

    Time and data storage can be saved by scanning an overview image of a whole slide; then, high resolution scans acquire only selected regions of interest.

  • Environmental control

    Multi-day, time lapse, and live cell assays can be run on the system. The software provides real-time monitoring of environmental state, ensuring optimal assay conditions. Product option includes humidity, CO2, and Ocontrol.

Applications of ImageXpress Pico Automated Cell Imaging System

  • Neurite Outgrowth / Neurite Tracing

    Neurite Outgrowth / Neurite Tracing

    Neurons create connections via extensions of their cellular body called processes. This biological phenomenon is referred to as neurite outgrowth. Understanding the signaling mechanisms driving neurite outgrowth provides valuable insight into neurotoxic responses, compound screening, and for interpreting factors influencing neural regeneration. Using the ImageXpress Micro system in combination with MetaXpress Image Analysis Software automated neurite outgrowth imaging and analysis is possible for slide or microplate-based cellular assays.

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  • Apoptosis Analysis

    Apoptosis Analysis

    Apoptosis is a process of programmed cell death important to a number of biological processes including embryonic development and normal tissue maintenance. Disruption in the regulation of apoptosis has been implicated in various diseases including cancer. Biochemical events lead to characteristic changes in cell morphology such as cell shrinkage, nuclear fragmentation, chromatin condensation, and mRNA decay, and ultimately cell death. Apoptosis can be initiated via the intrinsic or extrinsic pathways, and both pathways induce cell death by activating caspase enzymes

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  • Cell Proliferation

    Cell Counting

    Cell counting is fundamental and critical to numerous biological experiments. Assays such as drug compound toxicity, cell proliferation, and inhibition of cell division have a need to assess the number or density of cells in a well. Automated imaging can greatly speed up the cell counting process while reducing manual labor and human errors. Cells can be counted using a variety of methods, such as label-free cell counting under transmitted light or detection of nuclear dye with fluorescent imaging.

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Specifications of ImageXpress Pico Automated Cell Imaging System

Resources of ImageXpress Pico Automated Cell Imaging System

Videos and Demos

ImageXpress Pico System

Cellular images to results in minutes with automated imaging

Setting up acquisition and analysis on the ImageXpress Pico

Transmitted light cell scoring on the ImageXpress Pico

Reviewing completed experiments on the ImageXpress Pico

ImageXpress Pico Automated Cell Imaging System-Interactive Demo

ImageXpress Pico Automated Cell Imaging System

ImageXpress Pico Automated Cell Imaging System

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Ready to get started?

We are ready to help you solve your tough research challenges. Our proven solutions and highly qualified teams across the globe can help advance your next big discovery.

Ready to get started?

We are ready to help you solve your tough research challenges. Our proven solutions and highly qualified teams across the globe can help advance your next big discovery.