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Widefield imaging for basic research through to high-content screening

The ImageXpress® Micro 4 High-Content Imaging System is a high-throughput, widefield imager that can acquire images of whole organisms and cellular or intracellular events. It features proprietary fast frame rate technology, allowing for the capture of fast biological processes such as calcium oscillations in cardiomyocytes. It is highly configurable and adaptable to changing research needs. Available options include confocal, brightfield, phase contrast, liquid handing, and environmental control.

  • Expandable

    Support many cellular assays

    Image an incredible range of assays with various user-changeable filter cubes, 1-100x objectives, environmental control, fluidics option, and many sample formats including atypical plates for 3D assays.

  • Analyze images of more applications

    Analyze images of more applications

    A selection of feature-rich turnkey application modules is available with MetaXpress® software. For the development of novel assays, we offer an optional custom analysis module.

  • Tailor the system to meet your needs

    Tailor the system to meet your needs

    The imager is a highly flexible solution, you can add or change many of the components as your research priorities change. Examples include enhance light engines and automation.

ImageXpress Micro 4 Imaging

ImageXpress Micro 4 Imaging System

Features

  • Multiple imaging modes

    The system offers fluorescence, widefield, colorimetric, phase contrast, and brightfield label-free imaging. 

  • Field upgradeable to confocal

    The system can be upgraded to include the proprietary AgileOptix™ technology for accurate 3D volumetric analyses. 

  • Wide dynamic range

    Low and high intensity signal quantification in a single image with >3 log dynamic range intensity detection.

  • High speed image acquisition

    Using 4x magnification with a 1536-well plate, 225K wells per day can be acquired. Greater than a million wells per week can be imaged.

  • Optional environmental control

    Temperature, humidity, and CO2 control for multi-day live-cell imaging or fast kinetic studies are available.

  • Large magnification range

    Air and oil immersion objectives ranging from 1x to 100x are available for installation into the 4-position objective changer.

Introducing the MetaXpress 3D Analysis Toolkit

MetaXpress high-content image aquisition and analysis software

 

  • Meet high throughput requirements with a scalable, streamlined workflow
  • Adapt your analysis tools to tackle your toughest problems, including 3D analysis
  • Schedule automatic data transfer between third-party hardware sources and secure database
  • Set up hundreds of routinely used HCS assays using MetaXpress software modules

Applications of ImageXpress Micro 4 High-Content Imaging System

  • 3D Cell Models

    3d Cell Models

    The development and integration of three-dimensional (3D) assay models are becoming popular to drive translational biology. Our ImageXpress® Micro Confocal High-Content Imaging System allows superior visualization of thick samples by minimizing background fluorescence and increasing sharpness, resulting in accurate image segmentation. Increase the biological relevance of your screening assays with a seamless integration between acquisition and analysis of cells in a 3D space to yield volume, intensity, and distance measurements.

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    Cancer Research

    Cancer Research

    Cancer researchers need tools that enable them to more easily study the complex and often poorly understood interactions between cancerous cells and their environment, and to identify points of therapeutic intervention. Learn about instrumentation and software that facilitate cancer research using, in many cases, biologically relevant 3D cellular models like spheroids, organoids, and organ-on-a-chip systems that simulate the in vivo environment of a tumor or organ.

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  • Cardiomyocytes

    Cardiomyocytes

    Stem cells differentiated into cardiomyocytes are used to screen early for potential toxicological effects of drugs, thus helping to avoid investment in development of drugs which will fail in clinical trials due to cardiac toxicity.

    Cell Counting

    Cell Counting

    Cell counting is fundamental and critical to numerous biological experiments. Assays such as drug compound toxicity, cell proliferation, and inhibition of cell division rely on the assessment of the number or density of cells in a well.

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  • Cell Migration Assays

    Cell migration assays

    The movement or migration of cells is often measured in vitro to elucidate the mechanisms of various physiological activities such as wound healing or cancer cell metastasis. Cell migration assays may be conducted in a controlled environment using live cell timelapse imaging.

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    COVID-19 and Infectious Disease Research

    COVID-19 and Infectious Disease Research

    Here we've addressed common applications in infectious disease research including cell line development, binding affinity, viral neutralization, viral titer and more with a focused effort on understanding the SARS-CoV-2 virus in order to develop potential therapies for COVID-19 including vaccines, therapeutics and diagnostics.

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  • Live Cell Imaging

    Live Cell Imaging

    Live cell imaging is the study of cellular structure and function in living cells via microscopy. It enables the visualization and quantitation of dynamic cellular processes in real time. Live cell imaging encompasses a broad range of topics and biological applications—whether it is performing long-term kinetic assays or fluorescently labeling live cells.

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    Neurite Outgrowth / Neurite Tracing

    Neurite Outgrowth

    Neurons create connections via extensions of their cellular body called processes. This biological phenomenon is referred to as neurite outgrowth. Understanding the signaling mechanisms driving neurite outgrowth provides valuable insight into neurotoxic responses, compound screening, and for interpreting factors influencing neural regeneration. Using the ImageXpress Micro system in combination with MetaXpress Image Analysis Software automated neurite outgrowth imaging and analysis is possible for slide or microplate-based cellular assays.

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  • Stem Cell Research

    Stem Cell Research

    Pluripotent stem cells can be used for studies in developmental biology or differentiated as a source for organ-specific cells and used for live or fixed cell-based assays on slides or in multi-well plates. The ImageXpress system has utility in all parts of the stem cell researcher’s workflow, from tracking differentiation, to quality control, to measuring functionality of specific cell types.

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    Toxicity Screening

    Toxicity Screening

    Screening for off-target or toxic effects is very important during the development of new drugs and for the extension of the therapeutic potential of existing molecules. ImageXpress systems are fully integrated hardware and software platforms for automated acquisition and analysis of images for high-throughput cell-based cytotoxicity testing. Configured with optional environmental control, living cell responses or kinetic reactions can be monitored in real time for several days.

    Read Application Note 

Specifications & Options of ImageXpress Micro 4 High-Content Imaging System

Resources of ImageXpress Micro 4 High-Content Imaging System

Presentations
Videos & Webinars
Unleash the power of cell painting

Unleash the power of cell painting

Transitioning high-content assays to 3D

Transitioning high-content assays to 3D: Scientific opportunities and imaging challenges

Accelerate your Screening with Automated Imaging

Accelerate your screening with high-content and automated imaging

Microplate based Detection

Accelerating study of viral infection and therapeutics with microplate-based detection and high-throughput screening

Magnetic 3D

Magnetic 3D Bioprinting, 3D Cell Culture in a 2D Workflow

Labtube Meets SLAS

LabTube Meets Molecular Devices & MIMETAS, Susan Murphy & Sebastiaan Trietsch

Plate annotation and curve fitting in MetaXpress

Plate annotation and curve fitting in MetaXpress

Plate acquisition on ImageXpress Micro Confocal using MetaXpress

Quickstart Guide: Plate acquisition on the ImageXpress Micro Confocal using MetaXpress

Review images on ImageXpress Micro Confocal using MetaXpress

Quickstart Guide: Review images on the ImageXpress Micro Confocal using MetaXpress

Image analysis on ImageXpress Micro Confocal using MetaXpress

Basic workflow from image acquisition to analysis on the ImageXpress Micro Confocal using MetaXpress

Developing High Throughput Organ on a Chip Tissue

Developing high-throughput organ-on-a-chip tissue models for drug discovery using high-content imaging

3D Imaging of Cancer Spheroids

3D Imaging of Cancer Spheroids

Whole Organism Imaging

Whole Organism Imaging

High-Content Screening for Identifying miRNAs

High-Content Screening for Identifying miRNAs

Identification of Selective Inhibitors of the STAT3 Signaling Pathway

Identification of Selective Inhibitors of the STAT3 Signaling Pathway

Oliver Kepp and Jayne Hesley - Detect Cell Death Signatures with High Content Imaging

Oliver Kepp and Jayne Hesley - Hallmarks of Cancer - Detect and Quantify Cell Death Signatures with High Content Imaging

ImageXpress Micro 4 Imaging

ImageXpress Micro 4 Imaging System

Multidimensional ImageXpress Micro Confocal System

Multidimensional High-Throughput Imaging with the New ImageXpress Micro Confocal System

Pushing the Boundaries of High Content Screening

Pushing the Boundaries of High Content Screening

Preparing Assays for Genome-wide RNAi Screens

Preparing Assays for Genome-wide RNAi Screens Using High Content Microscopy

Multiplexed High Content Hepatoxicity Assays

Multiplexed High Content Hepatoxicity Assays Using iPSC-Derived Hepatocytes

High Content Imaging Analysis of Cell Sheet Morphogenesis Utilizing in Virto Tissue Models

High Content Imaging Analysis of Cell Sheet Morphogenesis Utilizing 𝘪𝘯 𝘷𝘪𝘵𝘳𝘰 Tissue Models

Simple and Flexible High Content Imaging of Complex Biological Events

Simple and Flexible High Content Imaging Enabling Quantitation of Complex Biological Events

Contemporary Automation and High Content Imaging Tools

Contemporary Automation and High Content Imaging Tools for Screening Stem Cell-Derived Cardiomyocytes

3D Image Analysis from Subcellular Structures to Spheroids

Implement High-Throughput 3D Image Analysis for Samples from Subcellular Structures to Spheroids

Live Cell Imaging to Investigate Cell Division Timing

Live Cell Imaging to Investigate the Regulation of Cell Division Timing

High-throughput RNA Screening to Identify Host Factors

Using High-throughput RNA Screening to Identify Host Factors That Impact Viral Infection

Application of HCA Tools for Antibody Drug Discovery

Application of HCA Tools for Antibody Drug Discovery

3D Spheroid Assays Using High-Content Imaging

Setting up 3D Spheroid Assays Using High-Content Imaging

Pluripotent Stem Cell Applications in Drug Discovery

Emerging Induced Pluripotent Stem Cell Applications in Drug Discovery

Related Products & Services of ImageXpress Micro 4 High-Content Imaging System

Expand your research using flexible imaging solutions

Molecular Devices provides flexible options for the ImageXpress Micro 4 High-Content Imaging System to meet your research needs and to easily capture images from different sample formats, including hanging drops and in round or flat bottom plates, for monitoring cell health kinetics under environmental control, and more. With over 30+ years of imaging expertise, we can help you select the right options to ensure the best images for your assay.

 

 

 

Implement a solution that works for you

Molecular Devices can successfully tailor the ImageXpress Micro 4 High-Content Imaging System to include customized software and hardware including the features described herein, as well as integration of other lab components such as incubators, liquid handlers, and robotics for a fully automated workcell. With over 30 years of experience in the life science industry, you can count on us to deliver quality products and provide worldwide support.

Sale is subject to our Custom Product Purchase Terms available at www.moleculardevices.com/custom-products-purchase-terms