ImageXpress Confocal HT.ai High-Content Imaging System
A scalable, high-throughput, high-content screening solution with 7-channel high-intensity laser light source and machine learning capabilities.
A scalable, high-throughput, high-content screening solution with 7-channel high-intensity laser light source and machine learning capabilities.
The ImageXpress® Confocal HT.ai High-Content Imaging System utilizes a seven-channel laser light source with eight imaging channels to enable highly multiplexed assays while maintaining high throughput by using shortened exposure times. Water immersion objectives improve image resolution and minimize aberrations so scientists can see deeper into thick samples.
The powerful combination of MetaXpress® software and IN Carta® software simplifies workflows for advanced phenotypic classification and 3D image analysis with machine learning capabilities and an intuitive user interface.
Capture images faster with shorter exposure times. Multiplex your experiments with 7 lasers and 8 imaging channels.
Custom Module Editor 3D analysis is optimized for confocal imaging, enabling 3D measurements of volume and distance.
Wide field of view enables whole-well confocal imaging and eliminates missed targets. Next-generation dual microlens enhanced spinning disk technology provides a large, flat field of view for more accurate and reproducible analysis.
Provides increased sensitivity with specially designed optics, high-powered laser illumination, and sCMOS sensor. Swappable disk geometries provide flexibility between speed and resolution.
Leverages machine learning to improve the accuracy and robustness of high-content image analysis, delivering data insights that other technologies miss. Reduces the complexity of image analysis with intuitive guided workflows in a modern user interface.
The system offers phase contrast and brightfield label-free imaging, widefield and confocal fluorescent imaging with water immersion optics as a standard option.
Offers greater image resolution and sensitivity with up to 4x increase in signal leading to lower exposure times.
Quantifies low and high intensity signals in a single image with >3 log dynamic range intensity detection.
Powerful analytics combined with an intuitive user interface simplify workflows for image analysis and phenotypic profiling. Advanced features provide the functionality you need to analyze data in 2D, 3D, and 4D - at scale - and deliver real-time insights without the need for complex pre- or post- processing operations. Improve specificity of your image analysis workflows by utilizing the SINAP deep-learning module and see for yourself that Segmentation Is Not A Problem. Put machine learning to work for you and perform complex phenotypic analysis within a user-friendly Phenoglyphs module.
Three-dimensional (3D) cell models are physiologically relevant and more closely represent tissue microenvironments, cell-to-cell interactions, and biological processes that occur in vivo. Now you can generate more predictive data by incorporating technologies like the ImageXpress system with the integrated 3D Analysis Module in MetaXpress® software. This single interface will enable you to meet 3D acquisition and analysis challenges without compromise to throughput or data quality, giving you confidence in your discoveries.
Cancer researchers need tools that enable them to more easily study the complex and often poorly understood interactions between cancerous cells and their environment, and to identify points of therapeutic intervention. Learn about instrumentation and software that facilitate cancer research using, in many cases, biologically relevant 3D cellular models like spheroids, organoids, and organ-on-a-chip systems that simulate the in vivo environment of a tumor or organ.
Cell Painting is a high-content, multiplexed image-based assay used for cytological profiling. In a Cell Painting assay, up to six fluorescent dyes are used to label different components of the cell including the nucleus, the endoplasmic reticulum, mitochondria, cytoskeleton, the Golgi apparatus, and RNA. The goal is to “paint” as much of the cell as possible to capture a representative image of the whole cell.
One common way of culturing cells in three dimensional space is through the use of extracellular matrix-based hydrogels, such as Matrigel. Cells are grown in an extracellular matrix (ECM) to mimic an in vivo environment. Differences between Matrigel and 2D cell cultures can be readily seen by their different cell morphologies, cell polarity, and/or gene expression. Hydrogels can also enable studies on cell migration and 3D structure formation, such as endothelial cell tube formation in angiogenesis studies.
Here we've addressed common applications in infectious disease research including cell line development, binding affinity, viral neutralization, viral titer and more with a focused effort on understanding the SARS-CoV-2 virus in order to develop potential therapies for COVID-19 including vaccines, therapeutics and diagnostics.
The drug discovery landscape is shifting, with more scientists centering cell line development, disease models, and high-throughput screening methods around physiologically-relevant 3D cell models. The reason for this is clear: Using cellular model systems in research that closely mimic patient disease states or human organs can bring life-saving therapeutics to market – faster.
Live cell imaging is the study of cellular structure and function in living cells via microscopy. It enables the visualization and quantitation of dynamic cellular processes in real time. Live cell imaging encompasses a broad range of topics and biological applications—whether it is performing long-term kinetic assays or fluorescently labeling live cells.
Neurons create connections via extensions of their cellular body called processes. This biological phenomenon is referred to as neurite outgrowth. Understanding the signaling mechanisms driving neurite outgrowth provides valuable insight into neurotoxic responses, compound screening, and for interpreting factors influencing neural regeneration. Using the ImageXpress Micro system in combination with MetaXpress Image Analysis Software automated neurite outgrowth imaging and analysis is possible for slide or microplate-based cellular assays.
Organoid technology, like organ-on-a-chip emulates organ physiology though co-culture of cells in a supportive 3D matrix and use of microfluidic channels to perfuse nutrients or compounds over the resulting cellular structures. It is rapidly gaining popularity as a biologically relevant screening model for new drugs and toxicity.
Organoids are three-dimensional (3D) multi-cellular microtissues that are designed to closely mimic the complex structure and functionality of human organs. Organoids typically consist of a co-culture of cells which demonstrate a high order of self-assembly to allow for an even better representation of complex in vivo cell responses and interactions, as compared to traditional 2D cell cultures.
Spheroids are multi-cellular 3D structures that mimic in vivo cell responses and interactions. They can be highly reproducible and to be scaled for high-content screening. Compared with adherent cells grown in 2D monolayers, 3D growth conditions are believed to more closely reflect the natural environment of cancer cells. Acquiring measurements from these larger structures involve acquiring images from different depths (z-planes) within the body of the spheroid and analyzing them in 3D, or collapsing the images into a single 2D stack before analysis.
Pluripotent stem cells can be used for studies in developmental biology or differentiated as a source for organ-specific cells and used for live or fixed cell-based assays on slides or in multi-well plates. The ImageXpress system has utility in all parts of the stem cell researcher’s workflow, from tracking differentiation, to quality control, to measuring functionality of specific cell types.
Toxicology is the study of adverse effects of natural or man-made chemicals on living organism. It is a growing concern in our world today as we are exposed to more and more chemicals, both in our environment and in the products we use.
Flyer
Molecular Devices has global leadership in the scale-up and industrial manufacture of human-derived 3Dorganoids using our proprietary bioprocess. Organoids offer significant benefits ov…
Blog
We caught up with Laura Dranschak, Director of Commercial Operations & Custom Solutions, to catch up on all things SLAS 2023. See what all the buzz was about on the show floor,…
Scientific Poster
3D bioprinting enables the generation of complex models with spatial control and a variety of matrices allowing the formation of complex tissue structures. Here we describe a method for…
Blog
The drug discovery landscape is changing. Bringing a drug to market has historically been time-consuming and costly, with many candidates failing in the first phase of clinical trials…
Application Note
Compound library screens using 2D monolayer cancercell lines are commonly performed in the pharmaceutical industry, to identify molecules with therapeutic potential. Multiple analogues…
Application Note
In drug discovery, the focus has shifted recently towards the development of compounds targeting the so-called ‘cancer stem cell’ populations within tumors. Non-specific, “Standard of…
Scientific Poster
Gene editing allows us to manipulate DNA through deletions, additions, or other modifications using several tools. There are numerous efficient strategies to carry out these modifica…
Scientific Poster
Most potential oncology drugs fail at the later stages of the drug development pipeline and in clinical trials, despite having promising data for their efficacy in vitro. This high f…
Application Note
Many oncology drugs fail at the later stages of the drug development pipeline and in clinical trials, despite promising data for their efficacy in vitro. This high failure rate is…
Scientific Poster
3D organoids are increasingly popular in drug discovery and disease modeling as they better represent biologically relevant microenvironments, tissue architecture, and functionality. Ho…
Blog
Target discovery and drug development rely heavily on 2D cell and animal models to decipher efficacy and toxic effect of drug candidates. Yet, 90% of candidates fail to make it past…
News
SAN JOSE, Calif., and UTRECHT, Netherlands, Feb. 13, 2023 – Molecular Devices, LLC., a leading provider of high-performance life science solutions, and HUB Organoids (HUB), the pioneer…
Blog
Introduction – the problem. The average cost of bringing a new drug to the clinic is around $1 billion according to a study conducted by the London School of Economics in March 2020…
Blog
As we enter the era of sophisticated drug discovery with gene therapy and personalized medicine, we need to be prepared to study complex diseases, assess the therapeutic effect of…
Publications
More researchers are using gene editing to build disease models that better represent human tissues' complex biology, signaling a shift away from 2D cell culture or animal models to…
Publications
3DPrint.com, the leading source for actionable intelligence related to 3D printing technology and the larger AM industry, covers our collaboration…
Publications
Following our acquisition of Cellesce Ltd, Tanya Samazan from Instrument Business Outlook dove deep into conversation with Molecular Devices President Susan Murphy and Cellesce CEO V…
News
Turnkey platform integrates flexible robotic automation with high-content imaging of complex 3D cellular models, enabling high-volume organoid screening SAN JOSE, Calif., Jan. 4, 2023…
Brochure
The BioAssemblyBot® 400 is an intelligent robot used by life scientists to build 3D model systems with increased throughput and precision, alleviating major concerns mentioned above.…
News
First-of-its-kind technology from Cellesce creates consistent patient-derived organoids for large scale drug screening Acquisition strengthens Molecular Devices’ position as a 3D…
Publications
Gone are the days of only measuring single parameters in cell-based experiments. Instead, researchers should widen their focus, namely with the help of innovations like the Cell Pain…
Scientific Poster
Most potential oncology drugs fail the drug development pipeline, despite having promising data for their efficacy in vitro. This further incentivize the need for identifying in vitr…
Scientific Poster
Three-dimensional (3D) cell models that represent various tissues are being successfully used in drug discovery and disease modeling to study complex biological effects and tissue ar…
Publications
We recently partnered with HeartBeat.bio to automate and scale the production of cardioids — 3D cell models of the heart that can more accurately recapitulate human biology.
…
Publications
In April 2021, we launched our Organoid Innovation Centre (OIC), an initiative designed to help scientists leverage the potential of 3D biology throughout the drug discovery process.…
eBook
Complex biological systems such as spheroids, organoids, and organ-on-a-chip are becoming more popular for disease modeling and drug screening as they better simulate organs and tiss…
Blog
SLAS Europe 2022, hosted numerous sessions packed with the latest research on emerging topics as well as sessions and panel discussions focused on how to build, and succeed, in a…
Blog
It was another great year at ISSCR 2022! Leaders from across the globe came together to discuss new technologies, share insights, and explore the newest breakthroughs in stem cell…
Publications
Today, nine out of ten drugs fail in clinical trials. Furthermore, it takes over a decade and an average cost of $2 billion to develop and approve each…
Scientific Poster
The culture of complex organoids such as the cerebral organoid is a rapidly developing technology that has immense potential in areas of developmental neurobiology and neurodegenerat…
Scientific Poster
3D cell models representing various tissues were successfully used for studying complex biological effects and tissue architecture, however, the complexity of 3D models remains a hur…
Blog
3D cell models are becoming increasingly popular for studying complex biological effects, tissue functionality, and diseases. Their ability to self-organize and mimic…
Application Note
3D cellular models are increasingly popular in many areas of research because they recapitulate the cellular 3D microenvironment better than cells grown in 2D monolayer.
eBook
Three-dimensional (3D) organoid development is one of the most important advancements in drug discovery research to date.
Application Note
Triple negative breast cancer is a clinically aggressive tumor subtype, with high rates of metastasis, recurrence, and drug resistance.
Publications
Cell painting is a high-content profiling technology that uses up to six fluorescent dyes to visualize specific cellular components at the single-cell level. The assay essentially “p…
Brochure
Core Life Analytics’ StratoMineR™ software helps biologists analyze the complex data derived from high-content image analysis. A powerful, intuitive workflow allows users to port dat…
Application Note
Cell painting has become a popular screening method within the drug discovery community. This phenotypic screening platform leverages advances in high-content microscopy, high-…
Publications
Three-dimensional (3D) cell-based assays replace a host of tissue, cell, and animal test models but have a reputation for lacking time resolution. For e…
Scientific Poster
Multiparametric high-content screening approaches, such as the Cell Painting assay, are increasingly being used in many applications ranging from drug discovery programs to functiona…
Scientific Poster
There is a critical need for biological model systems that better resemble human biology. Three-dimensional (3D) cell models and organ-on-a-chip (OoC) structures representing various…
Scientific Poster
Here we describe a workflow for automation of organoid culture. The automated method utilizes an integrated work-cell, consisting of several instruments providing automated cell cult…
Application Note
Label-free cell analysis provides a better alternative to using fluorescent dyes as it enables scientists to image live cells under near-native conditions – examining biological…
Flyer
The Organoid Innovation Center showcases cutting-edge instruments that work harmoniously together for autonomous, long-term, 3D and 2D live cell culture growth and monitoring with in…
Blog
SLAS2022, the Society for Lab Automation and Screening conference offered another exciting year for learning about innovative laboratory technologies. Whether you attended in-person…
Application Note
Image-based phenotypic profiling approaches such as the widely used Cell Painting assay use high-content imaging along with multiparametric readouts to study biological, genetic, and…
Scientific Poster
3D cell culture as a model system is increasingly popular because it recapitulates the in vivo microenvironment better than 2D cell cultures. Organoids have the capacity for stable d…
Scientific Poster
Triple negative breast cancer is a clinically aggressive tumor subtype, with high rates of metastasis, recurrence, and drug resistance. Currently there are no clinically approved sma…
Scientific Poster
Image-based phenotypic profiling approaches, such as the widely-used Cell Painting assay, use high-content imaging along with multiparametric readouts to study biological, genetic, a…
Application Note
Complex 3D biological models such as organoids and patient-derived spheroids are gaining popularity in many biomedical research areas because they more closely recapitulate the in vivo…
Blog
If you didn't get a chance to visit us at our poster sessions during ISSCR 2021, don’t fret. We've gathered all our sessions right here for you. The ISSCR Annual Meeting brought…
Application Note
We describe an automated integrated system that would allow automated monitoring, maintenance, and characterization of growth and differentiation of organoids and stem cells, as well…
Scientific Poster
3D cell models representing various tissues were successfully used for studying complex biological effects, tissue architecture, and functionality. However, the complexity of 3D mode…
Scientific Poster
Cerebral organoids are a rapidly developing technology that has great potential for understanding brain development and neuronal diseases. They can also be used for testing effects o…
Publications
Lab Manager speaks to Dan O’Connor, vice president, drug discovery, Molecular Devices, about the company’s Organoid Innovation Center in San Jose, CA. The center is 180 sq. ft., with…
Publications
Humans began culturing animal cells and tissues as early as the late 19th century, when Wilhelm Roux first showed that chick embryos could be cultured in saline solution for a few da…
Application Note
Culturing cell models in 3D has the advantage of recreating a more 𝘪𝘯 𝘷𝘪𝘷𝘰-like cell environment. With this improved physiological relevance comes a variety of considerations to…
Brochure
IN Carta™ Image Analysis Software solves complex image analysis problems utilizing advanced Artificial Intelligence (AI) turning images into data. Easy-to-use workflows help you get…
Blog
There have been significant advancements in microscopy and camera technology, as well as advancements in technologies for labeling molecules of interest over the past decade. These…
Blog
Thanks to recent advances in imaging technologies, we are now able to observe and analyze complex cellular networks in three dimensions. Through 3D imaging, we can acquire and…
Publications
Molecular Devices, a provider of innovative life science technology, recently unveiled a brand new, first-of-its-kind Organoid Innovation Center. Situated at the company’s global hea…
Application Note
Organoid models have increasingly gained popularity in biologic research and screening to recapitulate complexity of real tissues. To model the in vivo human lungs, we have cultured…
Brochure
The ImageXpress® Confocal HT.ai High-Content Imaging System utilizes a seven-channel laser light source with eight imaging channels to enable highly multi-plexed assays while maintai…
Blog
Artificial intelligence (AI) is finding its way into many aspects of modern life, from autonomous vehicles to voice-powered personal assistants, and even the creation of art. But it…
Publications
There is an increasing interest in using three-dimensional (3D) cell structures for modeling tumors, organs, and tissue to accelerate translational research. We describe here a novel…
Blog
Cheryl Bell talks about making the transition from manual microscopy to automated microscopy Our Field Applications Scientist, Cheryl Bell, was recently featured in a Women in…
Scientific Poster
There is an increasing interest in using three-dimensional (3D) cell structures for modeling tumors, organs, and tissue to accelerate translation research. Significant progress has b…
Blog
Have you ever heard the old adage, “A picture is worth a thousand words?” When it comes to Cell Painting, this saying is especially true. Cell Painting is a high-content,…
Publications
It has been a busy beginning of the year for Danaher’s Life Sciences segment. In January, the business reported 2020 revenues of $10.6 billion, represen…
Scientific Poster
In this study, we demonstrate improvement in assay sensitivity, precision, and speed of acquisition with a new configuration of the ImageXpress® Confocal HT.ai High-Content Imaging S…
Scientific Poster
Multiparametric high-content screening approaches, such as the Cell Painting assay, are increasingly being used in many applications ranging from drug discovery programs to functiona…
Scientific Poster
Organoid models have increasingly gained popularity in biologic research and screening to recapitulate complexity of real tissues. To model the in vivo human lungs, we have cultured…
Application Note
Here, we demonstrate improvement in assay sensitivity, quality, and speed of acquisition with the ImageXpress® Confocal HT.ai, our high-content imaging laser-based system.
Application Note
Here, we present a complete workflow for a cell painting assay that can be easily implemented using the ImageXpress Micro system and image analysis with machine learning capabilities
eBook
Gain insights and expedite studies for 2D and 3D cellular structures using automated cellular imaging.
Blog
For over 40 years, Molecular Devices has been at the forefront of technological advances which have contributed to significant scientific breakthroughs. To kick off the new year, we…
Application Note
Known as lab-on-a-chip systems, microfluidics gained popularity for its demonstrated success manipulating small volumes of fluid to control chemical, biological, and physical processes.
Blog
Kayla Hill discusses the latest trends in cellular imaging We recently hosted a webinar with our Field Applications Scientist, Kayla Hill, PhD, who explored high-content analysis…
Scientific Poster
Angiogenesis is the physiological process of formation and remodeling of new blood vessels and capillaries from pre-existing blood vessels.1 This can be achieved through e…
Application Note
3D spheroid models for cancer research are gaining popularity because they better mimic the in vivo tissue architecture, gene expression and metabolic profile of tumors compared to…
eBook
Investigate diverse 3D models and resolve common challenges experienced in 3D cell culture assays.
Scientific Poster
Cell-based phenotypic assays have become an increasingly attractive alternative to traditional in vitro and in vivo testing in pharmaceutical drug development and toxicological safet…
Application Note
Angiogenesis is the physiological process of formation and remodeling of new blood vessels and capillaries from pre-existing blood vessels. This can be achieved through endothelial…
Application Note
The FLIPR Penta system is powered by a high-speed EMCCD camera and the new ScreenWorks Peak Pro 2 software. The system allows measurement and analysis of complex patterns of calcium…
Scientific Poster
There is an increasing interest in using three-dimensional (3D) cell structures for modeling tumors, organs, and tissue to accelerate translation research.1 Significant progress has…
Scientific Poster
Cell-based phenotypic assays have become an increasingly attractive alternative to traditional in vitro and in vivo testing in pharmaceutical drug development and toxicological safet…
Application Note
Mitochondria are the main energy source for cells and play a key role in regulating cellular metabolism. Mitochondria can change their structures depending on environmental conditions…
Scientific Poster
To speed up the development of more effective and safer drugs, there is an increasing need for more complex, biologically relevant and predictive cell-based assays for drug discovery…
Scientific Poster
The purpose of these studies was to determine if water immersion objectives, used to improve image quality in complex biological assays, could be used in a high-throughput environmen…
Flyer
Gain the sensitivity to capture more phenotypic data at greater depths. Our high-content imagers and expert team are here to help your lab simplify imaging and analysis of complex, 3…
Application Note
Angiogenesis, the formation of new blood vessels from existing ones, is a critical step involved in various biological processes, such as endothelial sprouting, proliferation,…
Application Note
The movement or migration of cells has long been studied to elucidate the physiological mechanisms of angiogenesis, embryogenesis, cancer metastasis, immune responses, and wound…
Flyer
Capture more data at greater depths for 3D and thick tissue samples Scalable, high-performance, high-content screening solutions with the ImageXpress® Micro Confocal system
Presentations
Expertise in human iPSC-derived neural and cardiac platforms; Focus on adapting platforms to HTS and producing assay-ready solutions to accelerate drug discovery; Neural platform:…
Application Note
Understanding the impact of drugs on cardiac system early in the development process is critical to improve the safety of drugs getting to market. Cardiotoxicity is believed to be one…
Presentations
Learn more about the advantages and challenges of using 3D culture in phenotypic screening
Scientific Poster
Track contractility of each single cell within each population over long experimental times.
Application Note
The ability of mammalian cells to generate mechanical forces—to push, pull, or squeeze—is an intrinsic capability that is used by cells both individually and together as tissue to…
Scientific Poster
Screen models that mimic in vivo tumor microenvironment using novel 3D cell culture platform, VersaGel and Symphony
Scientific Poster
Effectively image and analyze cell migration using a scratch assay or a dissolvable biocompatible gel
Application Note
Most in vitro cell culture work is performed in two-dimensions (2D), where cells grow on a flat surface. However, culturing cells in 2D to screen drugs provides a limited picture of…
eBook
Gain valuable insights into neurobiology, from evaluation of ion channels to analysis of 3D neuron organoids.
eBook
This new eBook discusses early drug safety testing using HTS iPSC-derived cells with imaging. Download it now!
Scientific Poster
Test compound effects and screen for neurotoxic chemicals using 3D neural spheroids.
Infographic
Learn about the advantage and the technology behind 3D cellular image acquisition and analysis.
Application Note
Label-free cellular assays are required for a multitude of biological applications that monitor the cell number, proliferation, health, confluency, and cytotoxicity. In this…
Application Note
The ability to annotate your plate, plot your data into a graph, and produce a variety of curves and readouts including IC50 values and benchmark dose or concentration for your…
eBook
There has been significant progress in the development of 3D models and techniques during the last few years. Methods include biodegradable scaffolds, organ-on-a chip structures, or…
Scientific Poster
Three-dimensional (3D) in vitro models span the gap between two-dimensional cell cultures and whole-animal systems. By mimicking features of the in vivo environment and taking advant…
Brochure
Learn about our imaging family and which solution is best suited to answer your biological questions.
Brochure
Capture high-resolution images, recognize and segment objects, calculate parameters, and then translate your information into meaningful data. At Molecular Devices, we’re inspired by…
Scientific Poster
Development of predictive in vitro assays for early toxicity evaluation is extremely important for improving the drug development process and reducing drug attrition rates during cli…
Scientific Poster
The biopharma industry is continuing to adapt more cell-based assays for primary and secondary screening because of higher biological relevance and increased value of information.…
Application Note
Using high-content imaging assays allow cells cultured and treated in microplates to be imaged alive without wash steps for real-time studies of cells in their most natural state,…
Application Note
Cell models are becoming more complex in order to better mimic in vivo microenvironments and provide greater predictivity for compound efficacy and toxicity. There is an increasing…
Application Note
Establishment of physiologically-relevant in vitro models is crucial to further understanding of the mechanisms of neurological diseases as well as targeted drug development. While…
Application Note
Researchers are turning to three-dimensional (3D) cell culture as a way to increase the biological relevance of their disease models and predictive value of drug studies. These 3D…
Application Note
We have previously described the automated plating, treatment, and analysis of 3D spheroids formed in hanging drop
plates (see Automated 3D Cell Culture and Screening by Imaging…
Application Note
There is an increasing interest in using three-dimensional (3D) spheroids for modeling cancer and tissue biology to accelerate translational research. The goal of this study was to…
Application Note
Cellular transformation/tumorigenicity assays using cultures of cells in semi-solid media (soft agar or Matrigel) has been well established for cancer research1,2,5. The assay requires…
Application Note
There is increasing interest in exploring the use of three-dimensional (3D) spheroids for modeling developmental and tissue biology with the goal of accelerating translational research…
Application Note
In recent years, there has been significant progress in development of in vitro aggregates of tumor cells for use as models for in vivo tissue environments. When seeded into a well of…
Application Note
Many cancer cell lines will form spheroids if cultured on a favorable three dimensional (3D) matrix. These spheroids are believed to represent tumor physiology more closely than cells…
Application Note
The ImageXpress® Micro Confocal/ XLS Widefield High-Content Imaging System from Molecular Devices includes optional Fluidics and Environmental Control modules, enabling single-channel…
Application Note
The discovery and development of novel drugs is a difficult and expensive process due to lack of tools and techniques to accurately reproduce the human physiological response in the…
Application Note
Autophagy is an intracellular catabolic process that sequesters and degrades proteins and organelles that have either been recognized as faulty or are simply no longer needed by the…
Application Note
Screening of hybridoma supernatants for antibodies directed against cell-surface antigens is an important step in the discovery and development of antibodies for vaccines or…
Application Note
Recently, zebrafish-based screening has gained favor as an alternative to mammalian screening due to cost, throughput and reduced ethical concerns. Zebrafish are a useful model for…
Application Note
Apoptosis is an important mechanism signaling programmed death of cells in normal processes such as embryonic development, as well as in diseases including cancer and neurodegenerative…
Application Note
The nervous system is sensitive to the toxic effects of many chemical compounds, environmental agents and certain naturally occurring substances. Neurotoxicity can cause temporary or…
Application Note
The ability to monitor responses in living cells over a specific period of time offers cell biologists several key advantages for assay development. For routine cellbased screening,…
Application Note
Drug-induced hepatotoxicity is an important cause for liver injury and acute liver failure. Thus highly predictive assays for safety and efficacy testing are crucial for improving drug…
Application Note
Cardiac hypertrophy is a condition associated with many heart diseases such as myocardial infarction, ischemia, hypertension, valvular dysfunctions, and is also observed as a toxic…
Flyer
The ImageXpress® Micro Confocal High-Content Imaging System provides improved quantification for live or fixed cell assays. This versatile imaging system features a unique confocal t…
Scientific Poster
The absence of physiologically relevant in vitro models of the nervous system is an important limitation in using 3D cultures for assay development applicable for neurodegenerative d…
Scientific Poster
Explore PDF & learn the use of fast kinetic fluorescence and 3D image analysis for Phenotypic characterization of compound effects on iPSC-derived Cardiac and Liver Spheroids.…
Scientific Poster
for modeling developmental and tissue biology with the goal of accelerating translational research. Such 3D models can provide different perspectives from traditional 2D cultures on…
Scientific Poster
Learn how to improve sensitivity of DNA damage detection & genotoxicity sensitivity with confocal acquisition to detect nuclear punctae in a high throughput imaging assay.
Scientific Poster
Monitoring treatment effects on the cell cycle is particularly relevant to progressing oncology research and drug discovery. For instance, compounds known to inhibit mitosis are ofte…
Scientific Poster
Development of more complex, biologically relevant, and predictive cell-based assays for compound screening is one of the main challenges in drug discovery. There is an increasing in…
Scientific Poster
Read more about cell based assays for measuring the impact of pharmacological compounds on the rate of beating cardiomyocytes with different assay platforms.
Scientific Poster
There is an emerging interest in using three-dimensional (3D) organoid cultures for modeling tissue biology and cancer. Development of higher throughput assays to quantify phenotypic…
Brochure
Molecular Devices is a leading provider of high-performance bioanalytical measurement solutions for life science research, pharmaceutical development, and biotherapeutic discovery. O…
Brochure
Complex assays and three-dimensional cell models better represent tissue biology and cell interactions, making them more relevant for many toxicity and drug screening assays. The abi…
Scale Up Your Screening: Integrating Automation Into 3D Biology for Therapeutic Drug Discovery
Are Organoids the Future of Drug Discovery?
Automating 3D Organoid Models and Assay Workflows
Using Differentiated iPSCs to Build Ready-to-use 3D Models
The search for answers: Using lab automation with patient-derived tumoroids to find more relevant therapies for clinically aggressive cancers
3D Imaging Seminar Series
Intestinal organoids for automated screening assays
New standard in organoid culture and image-based analyses
The BAB400 integrated with the ImageXpress® Confocal HT.ai High-Content Imaging System
Automate your 3D biology high-throughput workflows
How 3D biology is shaping the future of drug discovery
Automation of the organ-on-a-chip assay: automated culture, imaging and analysis of angiogenesis
Challenges for drug screening of complex biological systems
3D Tissue Models Imaging and Automation of Organ-On-A-Chip
Introduction to the Organoid Innovation Center and ImageXpress Confocal HT.ai system
Level Up your 3D Cell Culture: From Research to High-Throughput
Enhance high-content 3D biology imaging with automated sample preparation
Enhancing 3D Disease Models: Automated, High-Throughput, Phenotypic Screening with Organ-on-a-Chip
High-Content Phenotypic Screening
Emerging Organoid Models: Translating Basic Research to Drug Development and Regenerative Medicine
ImageXpress Confocal HT.ai Overview
Application and Analysis of Organoid Systems
Automating culture and high-content imaging of 3D organoids for in vitro assessment of compound effects
Getting Started with 3D Human Tissue Models and Imaging
Capturing the Complexity of Cell Biology
ISSCR 2021 Innovation Showcase: Automated culture monitoring, imaging, and analysis of complex biological systems
Deep Learning-Based Image Analysis for Label-Free Live Monitoring of iPSC and 3D Organoid Cultures
Monitoring organoid development in iPSC-derived 3D cerebral organoids
ISSCR 2021 Innovation Showcase: Automated Culture and High-Content Imaging of 3D Lung and Cardiac
A physiologically-relevant 3D ECM for 𝘪𝘯 𝘷𝘪𝘵𝘳𝘰 oncology research and intelligent high-content imaging of 3D models
Organoid Innovation Center Walkthrough
Capturing the complexity of 3D biology: Organoids for disease modelling and toxicity research
Imaging and Analysis of a 3D Airway Organoid Model
ImageXpress Confocal HT.ai / IN Carta Image Analysis Software Introduction
Spheroid Z-stack
Spheroid 3D render
Spheroid 20X WI Deep Tissue 250 μm-Nuclei Mask-3D recon
Immunology and Vaccine Development Workflow
Hybridoma Workflow
Disease modeling in the 21st century: Automated organoid assays with 3D imaging
High-throughput, organoid-derived organ-on-a-chip systems for drug discovery and disease modelling
Unleash the power of Cell Painting
3D cell culture, tissue clearing, & high-content imaging in the quest of effective solutions to NAFLD
Transitioning high-content assays to 3D: Scientific opportunities and imaging challenges
Gain deeper insights into cellular 3D structures with water immersion objectives
An AI-based approach to high-content phenotypic characterization of human iPSC-derived neuronal cells
Implementing 3D Neural Spheroids in Drug Discovery
Accelerate your screening with high-content and automated imaging
Accelerating study of viral infection and therapeutics with microplate-based detection and high-throughput screening
ImageXpress Micro Confocal Virtual Tour
Magnetic 3D Bioprinting, 3D Cell Culture in a 2D Workflow
LabTube Meets Molecular Devices & MIMETAS, Susan Murphy & Sebastiaan Trietsch
Plate annotation and curve fitting in MetaXpress
Quickstart Guide: Plate acquisition on the ImageXpress Micro Confocal using MetaXpress
Quickstart Guide: Review images on the ImageXpress Micro Confocal using MetaXpress
Basic workflow from image acquisition to analysis on the ImageXpress Micro Confocal using MetaXpress
Developing high-throughput organ-on-a-chip tissue models for drug discovery using high-content imaging
Toxicity studies of iPSC-derived cardiomyocytes and neuronal spheroids
Optimizing high-content screening tools for physiologically-relevant 3D in vitro models
Morphological Characterization of 3D Neuronal Networks in a Microfluidic Platform
3D Imaging of Cancer Spheroids
High-Content Screening for Identifying miRNAs
Identification of Selective Inhibitors of the STAT3 Signaling Pathway
Oliver Kepp and Jayne Hesley - Hallmarks of Cancer - Detect and Quantify Cell Death Signatures with High Content Imaging
Multidimensional High-Throughput Imaging with the New ImageXpress Micro Confocal System
Pushing the Boundaries of High Content Screening
Preparing Assays for Genome-wide RNAi Screens Using High Content Microscopy
Multiplexed High Content Hepatoxicity Assays Using iPSC-Derived Hepatocytes
High Content Imaging Analysis of Cell Sheet Morphogenesis Utilizing 𝘪𝘯 𝘷𝘪𝘵𝘳𝘰 Tissue Models
Implement High-Throughput 3D Image Analysis for Samples from Subcellular Structures to Spheroids
Live Cell Imaging to Investigate the Regulation of Cell Division Timing
Using High-throughput RNA Screening to Identify Host Factors That Impact Viral Infection
Application of HCA Tools for Antibody Drug Discovery
Setting up 3D Spheroid Assays Using High-Content Imaging
Physiologically-Relevant Tissue Models Using a High-Throughput Organ-on-a-Chip Platform
Emerging Induced Pluripotent Stem Cell Applications in Drug Discovery
StemoniX microBrain 3D Assay Ready Plates for HTS
Latest Citations: For a complete list, please click here .
*Source: https://scholar.google.com/
Diclofenac, a nonsteroidal anti-inflammatory drug (NSAID) used to treat inflammatory diseases induces cellular toxicity by increasing the production of reactive oxygen species (ROS) and impairing autophagic flux. In this study, we investigated whether diclofenac induces cancer cell death and the mechanism by which diclofenac causes cell death. We observed that diclofenac induces mitotic arrest with a half-maximal effective concentration of 170 μM and cell death with a half-maximal lethal dose of 200 µM during 18-h incubation in HeLa cells. Cellular microtubule imaging and in vitro tubulin polymerization assays demonstrated that treatment with diclofenac elicits microtubule destabilization.
To investigate the effect of succinic acid on the development of experimental autoimmune uveitis (EAU) and the underlying mechanism.
The diverse modes of action of small molecule inhibitors provide versatile tools to investigate basic biology and develop therapeutics. However, it remains a challenging task to evaluate their exact mechanisms of action. We identified two classes of inhibitors for the p97 ATPase: ATP competitive and allosteric. We showed that the allosteric p97 inhibitor, UPCDC-30245, does not affect two well-known cellular functions of p97, endoplasmic-reticulum-associated protein degradation and the unfolded protein response pathway; instead, it strongly increases the lipidated form of microtubule-associated proteins 1A/1B light chain 3B (LC3-II), suggesting an alteration of autophagic pathways.
Increase efficiency and throughput with cloud-based advanced analytics
Transform your incredible images into captivating results
Molecular Devices provides flexible options for the ImageXpress Confocal HT.ai system to meet your research needs and to easily capture images from different sample formats, including hanging drops and in round or flat bottom plates, for monitoring cell health kinetics under environmental control, and more. With over 30+ years of imaging expertise, we can help you select the right options to ensure the best images for your assay.
20X, 40X, and 60X water immersion objectives improve the geometric accuracy during acquisition and reduce light refraction for brighter intensity at lower exposure times.
Our transmitted light tower enables acquisition of high contrast images for unstained cells which can be easily viewed or separated from background.
Environmental control maintains temperature and humidity levels while minimizing evaporation for multi-day, live cell, time-lapse imaging.
Molecular Devices can successfully tailor the ImageXpress Confocal HT.ai system to include customized software and hardware including the features described below, as well as integration of other lab components such as incubators, liquid handlers, and robotics for a fully automated workcell. With over 30 years of experience in the life science industry, you can count on us to deliver quality products and provide worldwide support.
Sale is subject to our Custom Product Purchase Terms available at www.moleculardevices.com/custom-products-purchase-terms
The deep tissue penetrating, confocal disk module reduces crosstalk to improve out-of-focus light suppression and penetrate deeper into tissue.
Schedule and image multiple plates over long periods of time while keeping consistent temperature, O2 (Hypoxia), CO2, and humidity conditions. Expand live cell walk-away capacity to 200+ plates.
Increase throughput, eliminate human errors, maintain sterility, and achieve consistent sample handling. Modular automation design—components can be added in modules and are upgradeable.
Specialized deep tissue penetrating, confocal disk module, combined with a laser light source, improves light penetrance for deeper tissue penetration, resulting in sharper images with improved resolution when imaging thick tissue samples†.
Images taken at the same exposure.
Three-dimensional (3D) cell models are physiologically relevant and more closely represent tissue…
Cancer researchers need tools that enable them to more easily study the complex and often poorly…
Cell Painting is a high-content, multiplexed image-based assay used for cytological profiling. In a…
One common way of culturing cells in three dimensional space is through the use of extracellular…
Here we've addressed common applications in infectious disease research including cell line…
The drug discovery landscape is shifting, with more scientists centering cell line development,…
Live cell imaging is the study of cellular structure and function in living cells via microscopy.…
Neurons create connections via extensions of their cellular body called processes. This biological…
Organoid technology, like organ-on-a-chip emulates organ physiology though co-culture of cells in a…
Organoids are three-dimensional (3D) multi-cellular microtissues that are designed to closely mimic…
Spheroids are multi-cellular 3D structures that mimic in vivo cell responses and interactions. They…
Pluripotent stem cells can be used for studies in developmental biology or differentiated as a…
Toxicology is the study of adverse effects of natural or man-made chemicals on living organism. It…
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![3D Biology: The paradigm shift in next-generation drug discovery [Interactive infographic]](/sites/default/files/2023-04/3d-biology-paradigm-next-gen-drug-discovery.jpg)
