ZMYND11 Links Histone H3.3K36me3 to Transcription Elongation and Tumour Suppression

Wen H, et al., 508(7495):263-8, Nature, 2014

The authors identified and performed structural and functional characterization of ZMYND11, an adenovirus early region 1A (E1A) interacting protein acts as a histone H3.3-specific reader of H3.3K36me3 (trimethylation modification of the histone). Regulation of RNA polymerase II elongation control by ZMYND11 was linked to tumor suppression. Binding kinetic studies were performed on the Octet RED96 system using Anti-GST antibody-coated biosensors.

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