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Explore automation-ready systems for your clone screening workflow

Mammalian and microbial clone screening projects traditionally begin with a target—a receptor, protein, or gene that participates in a biological pathway of interest. Next comes screening, where thousands to millions of cells are tested and analyzed in relation to the target. This presents a significant bottleneck for labs as it requires laborious and time-consuming methods across a wide range of analytical platforms.

With Molecular Devices automated clone screening workflows, you can ease the burden on your lab by significantly reducing hands-on-time while creating a central repository for data pulled from multiple processes. Our automated solutions unify all of your laboratory devices to increase your throughput and efficiency while reducing human interaction.

Automated cell line development workflow

Cell line development requires the discovery of single cell-derived clones that produce high and consistent levels of the target therapeutic protein. A critical first step in the process is the isolation of single, viable cells. Single cells proliferate to form colonies that can then be assessed for productivity of the target therapeutic protein. Viability and growth rates of single cell-derived clones are then characterized before final selection and scale-up.

 

Workcell integrated system solution:

  • CloneSelect Single-Cell Printer
  • CloneSelect Imager
  • SpectraMax iD5 Multi-Mode Microplate Reader
  • AquaMax Microplate Washer
  • Sartorius Octet BLI Label-Free Detection Systems
  • Beckman Coulter Biomek automated liquid handler
  • Bionex Solutions HiG4 automated centrifuge
  • LiCONiC LiCotel automated plate hotels
  • LiCONiC StoreX automated incubator

 

 

Automated molecular cloning workflow

Molecular cloning refers to the isolation of a DNA sequence from any species (often a gene), and its insertion into a vector for propagation, without alteration of the original DNA sequence. This is a very laborious process when done manually requiring hundreds of plates and kits. There are several areas where errors or contamination can occur. Automating the process can reduce FTE time by 50% while increasing throughput and efficiency two fold.

 

Workcell integrated system solution:

  • QPix Microbial Colony Pickers
  • SpectraMax Microplate Reader with SoftMax Pro GxP Software
  • Beckman Coulter Biomek automated liquid handler
  • LiCONiC StoreX automated incubator
  • Micronic Tube Capper/De-Capper
  • Plate labeler, sealer and peeler
  • Multidrop Combi
  • PCR Platform
  • Plate Centrifuge
  • Fragment analyzer

Resources of Lab automation for high throughput clone screening

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Advanced Workflow Engineering Solutions (AWES) Introductory

Qpix Overview Video

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