Validation of Aspergillus Fumigatus Glucosamine-6-phosphate N-acetyltransferase as a Potential Antifungal Target

Lockhart D, et al., 383:S69, The Lancet, 2014

The authors described the screening of small-moleculae ligands that bind to the antifungal target glucosamine-6-phosphate N-acetyltransferase (GNA1) from Aspergillus fumigatus. They showed that GNA is essential for cell viability in A. fumigatus and could also be a possible novel antifungal target. Binding studies were performed on the Octet RED system.

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