Translation Inhibition of the Developmental Cycle Protein HctA by the Small RNA IhtA is Conserved Across Chlamydia

Tattersall, J., et al., 7(10):e47439, PLoS One, 2012

HctA, a histone-like protein, is central to differentiation between cellular forms in the developmental cycle of Chlamydia trachomatis. The small RNA lhtA represses translation of HctA, allowing cell differentiation to proceed. This mechanism is shown here to be conserved across pathogenic chlamydial species. lhtA from each species tested was shown to interact with its related hctA target mRNA in vitro using the Octet QK<sup>e</sup> system and Streptavidin biosensors.

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