The Sphingolipid Receptor S1PR2 is a Receptor for Nogo-A Repressing Synaptic Plasticity

Kempf A, et al., 12(1):e1001763, PLoS Biol, 2014

This study describes how the authors identified and characterized a new G-protein Coupled Receptor (GPCR), S1PR2 which binds to Nogo-A, a membrane protein of the central nervous system (CNS) that possibly has a role in inhibiting nerve fiber regeneration of the CNS after injury. Kinetic binding studies were performed on the Octet RED system using Amine-Reactive biosensors. The results of the study suggest a more dynamic model of GPCR signaling that involves shared membrane components interacting and intramolecular cross talk to control regulation.

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