The P2/P2' sites Affect the Substrate Cleavage of TNF- α Converting Enzyme (TACE)

Liu S, et al., 62(1):122-128, Mol Immunol, 2014

The authors performed computation and functional analysis of the P2 and P2' sites of the proteinase tumor necrosis factor-alpha converting enzyme (TACE) to better understand the enzymatic mechanisms, catalytic domains and substrate cleavage and provide insight in to the design of novel TACE inhibitors. Real-time binding assays were performed on the Blitz system and Streptavidin biosensors were used.

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