The Depolymerized Fucosylated Chondroitin Sulfate from Sea Cucumber Potently Inhibits HIV Replication via Interfering with Virus Entry

Huang N, et al., 380, 64-69, Carbohydr Res, 2013

This work focuses on the anti-HIV activity of FuCS1, a low molecular weight fragment of a fucosylated chondroitin sulfate derived from the sea cucumber Thelenota ananas. The binding of FuCS1 to HIV-1 gp120 was investigated using the Octet RED96 system. The gp120 protein was loaded onto AR2G biosensors for these measurements.

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