Tetraspecific Ligand for Tumor-targeted Delivery of Nanomaterials

Kim D, Friedman AD, and Liu R, pii: S0142-9612(14)00389-5, Biomaterials, 2014

The authors generated a recombinant targeting ligand with tetraspecificity for four different cancer biomarkers to demonstrate synergistic binding effects of the ligand to act on the multiple signaling pathways for different cancer types and also exhibit the potential of nanomaterials with a wider tumor targeting range, potency and efficiency. Binding affinities of the ligands tested were performed on the Octet QK system and Anti-hIgG Fc capture (AHC) biosensors were used.

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