Synthesis and Initial Evaluation of YM-08, a Blood-Brain Barrier Permeable Derivative of the Heat Shock Protein 70 (Hsp70) Inhibitor MKT-077, Which Reduces Tau Levels

Miyata, Y, et al., 4(6), 930-939, ACS Chem Neurosci, 2013

This study reports on the synthesis and initial characterization of YM-08, a neutral small-molecule Hsp70 inhibitor designed for enhanced blood-brain barrier permeability. The Octet RED system was used to determine YM-08 binding affinities for Hsp70 nucleotide binding domain and for full-length Hsp70. Biotinylated Hsp70 proteins were loaded onto Super Streptavidin biosensors for these measurements.

Read More