Structure of MST2 SARAH Domain Provides Insights into Its Interaction with RAPL

Liu G, et al., 185(3):366-74, J Struct Biol, 2014

The authors performed structural and biochemical studies on the hetero-interaction and signaling of MST2, a STE20 kinase involved in the HIPPO pathway. Interaction as well as dimerization of MST2 is a catalyst to this kinases' apoptotic function in T cells. Kinetic analysis studies were performed using the Octet RED96 system with Streptavidin biosensors.

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