Structural Insights into Regulatory Mechanisms of MO25-mediated Kinase Activation

Hao Q, et al., 186(2):224-33, J Struct Biol, 2014

The authors perform structural and functional analysis on MO25, an adapter molecule and key component in the LKB1-STRAD-MO25 complex that acts as an upstream kinase for AMPK family of kinases. The work described the evolution of different regulator mechanisms of kinase activation that MO25 has a role in. Kinetic binding studies were performed on the Octet RED96 system and Streptavidin biosensors were used.

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