Structural Characterization of the Self-association of the Death Domain of p75NTR

Qu, Q, et al., 8(3):e57839, PLoS One, 2013

To elucidate the mechanism of regulation for the neurotrophin receptor p75NTR, the authors perform structural and functional analysis of truncations of the intracellular region. Crystal structures of intracellular death domain were reported showing two possible dimer arrangements. The Octet system and Streptavidin biosensors were used to measure kinetics of p75NTR binding to downstream adaptor protein RIP2 (CARD) domain in order to elucidate binding features of various oligomeric conformations of p75NTR intracellular region.

Read More