Structural Analysis of the Hemagglutinin from the Recent 2013 H7N9 Influenza Virus

Yang H, et al., 87(22), 12433-46, J Virol, 2013

This study is focused on hemagglutinins (HA) from the 2013 H7N9 influenza virus, assessing their receptor binding phenotype in relation to previously studied HAs. Two recombinant A(H7N9) HAs were structurally characterized, and a mutational study of the receptor binding site was performed to analyze important residues that can affect receptor preference and affinity. HA glycan binding selectivities were examined using Streptavidin biosensors loaded with biotinylated glycans on the Octet RED system.

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