Striatins Contain a Noncanonical Coiled Coil That Binds Protein Phosphatase 2A A Subunit to Form a 2:2 Heterotetrameric Core of Striatin-interacting Phosphatase and Kinase (STRIPAK) Complex

Chen C, et al., 289(14):9651-61, J Biol Chem, 2014

Striatins are novel regulatory subunits of protein phosphatase 2A (PP2A) that form supramolecular complexes called striatin-interacting phosphatase and kinase (STRIPAK) and have been shown to have a role in signal transduction, cytoskeleton dynamics, endocytosis and apoptosis. The authors performed the structural and biochemical studies on key residues of striatins to better understand the STRIPAK complex function. Binding studies were performed on the Octet RED96 system and Streptavidin biosensors were used.

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