Stimulation of the Retinoid X Receptor Facilitates Beta-Amyloid Clearance Across the Blood-Brain Barrier

Bachmeier, C, et al., 49(2), 270-6, J Mol Neurosci, 2013

The impact of retinoid X receptor stimulation on beta-amyloid protein (Aβ) clearance across the blood brain barrier was investigated. The Octet RED96 system was used to determine whether stimulation of Aβ(1-42) in the presence of bexarotene and fluorobexarotene was due to direct binding of the drugs to Aβ(1-42). No binding was apparent, although binding the Congo Red positive control was clearly detected. Super Streptavidin biosensors were loaded with Aβ(1-42) for these experiments.

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