Russell Body Inducing Threshold Depends on the Variable Domain Sequences of Individual Human IgG Clones and the Cellular Protein Homeostasis

Stoops, J., Byrd, S., Hasegawa, H., 1823(10), 1643-57, Biochimica et Biophysica Acta (BBA), 2012

Russel bodies are naturally-occuring aggregates of immunoglobulins. In this paper, an IgG panel was used to investigate the propensity of individual clones to induce Russell body formation under various cellular conditions. The Octet RED96 system with Protein A biosensors was used to determine human IgG concentrations in harvested culture media.

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