Publications

Receptor Binding by a Ferret-transmissible H5 Avian Influenza Virus

Xiong, X, et al., 497(7449), 392-6, Nature, 2013

This publication presents quantitative biophysical measurements of the receptor-binding properties of hemagglutinin from an H5 avian influenza virus transmissible mutant, and reports a dramatic increase in preference for binding of human over avian receptors. Virus binding to defined receptor analogues was measured using the Octet RED96 system. Biotinylated alpha2,3- and alpha2,6-sialic acid structures were loaded onto Streptavidin biosensors to generate equilibrium binding data.

Read More