Protuboxepin A, a Marine Fungal Metabolite, Inducing Metaphase Arrest and Chromosomal Misalignment in Tumor Cells

Asami, Y., et al., 20(12), 3799-3806, Bioorganic & Medicinal Chemistry, 2012

The authors identified protuboxepin A as a microtubule-stabilizing agent which has a distinctly different chemical structure from previously reported microtubule inhibitors. This publication reports Octet system data for binding of protuboxepin A to tubulin. The reported results indicate that protuboxepin A has potential for being a new and effective anti-cancer drug.

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