Potent Single-domain Antibodies that Arrest Respiratory Syncytial Virus Rusion Protein in its Prefusion State

Rossey I, et al., 8:14158, Nat Commun, 2017

Human respiratory syncytial virus (RSV) is a major cause of respiratory infection in children. The prefusion form of RSV F protein is a known target for development of antiviral therapies. Rossey et. al. used an Octet HTX instrument to perform a cross-competition assay between two camelid antibodies that they created and several monoclonal antibodies that bind F protein, allowing them to distinguish which antibodies bind to the same epitopes as their camelid antibodies.

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