Potent Neutralization of Vaccinia Virus by Divergent Murine Antibodies Targeting a Common Site of Vulnerability in L1 Protein

Kaever T, et al., pii: JVI.01491-14, J Virol, 2014

In this report, the researchers developed and characterized potent neutralizing antibodies against vaccinia virus L1 protein, a key target in small pox vaccine. Multiple methodologies were used to provide a better understanding of the neutralizing epitopes on L1 and the neutralizing mechanizing of anti-L1 antibodies. Real time binding assays were performed using the Octet RED96 instrument and Ni-NTA (NTA) biosensors.

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