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Potent Dengue Virus Neutralization by a Therapeutic Antibody with Low Monovalent Affinity Requires Bivalent Engagement

Edeling MA, et al., 10(4):e1004072, PLoS Pathog, 2014

In this study, the authors performed analysis to better understand the structural and mechanistic basis for the neutralization activity of E106, a monoclonal antibody which protected against the lethal Dengue virus type 1 infection in mice by bivalent engagement of the adjacent domain III subunits on a single virion. The binding kinetics of the mAB and Fabs were performed on the Octet RED system using Streptavidin biosensors. These studies shed new insight into the humoral response against flaviviruses.

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