Publications

Plasmodium Falciparum Aldolase and the C-terminal Cytoplasmic Domain of Certain Apical Organellar Proteins Promote Actin Polymerization

Diaz S, et al., 197(1-2):9-14, Mol Biochem Parasitol, 2014

This investigation tried to deepen the understanding of the interactome involved in apicomplexan motility and host cell invasion pertaining to Plasmodium falciparum (Pf). In particular, they investigated the interactions between actin, several cytoplasmic tail domains (CTD), and aldolase. Using an Octet RED96 system, they showed that Pf aldolase binds with high affinity to both rabbit and Pf actin. The investigation also determined that Pf aldolase has a similar affinity for filamentous (F-) actin and globular (G-) actin. Both G and F actin were biotinylated and immobilized on to SA sensors during this investigation.

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