Pharmacologic Profile of the Adnectin BMS-962476, a Small Protein Biologic Alternative to PCSK9 Antibodies for Low-Density Lipoprotein Lowering

Mitchell T, et al., 350(2):412-24, J Pharmacol Exp Ther, 2014

The authors performed structural and functional characterization on a new class of high affinity binding agents known as adnectins which interact with the proprotein convertase subtilisin/kexin type 9 (PCSK9) protein to regulate LDL levels. Adnectins exhibited many of the functional properties of inhibitory mAb to PCSK9 but their molecular size is in between that of peptides and immunoglobulins. The binding studies were performed on the Octet RED 96 system using Super Streptavidin biosensors.

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