Peptide Inhibitor of Japanese Encephalitis Virus Infection Targeting Envelope Protein Domain III

Zu X, et al., 104C:7-14, Antiviral Res, 2014

In this study, the authors screened a phage display library and identified a unique peptide designed "P3" that specifically binds and interacts with the Japanese encephalitis virus (JEV) Domain III envelope glycoprotein (E DIII) specifically at the N terminus to block virus attachment to the cell and inhibit viral infection. This is the first report of a peptide which binds to sites on JEV E DIII but not cellular receptors to interfere with JEV infection. Binding analysis was performed on the Octet QK system.

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