Novartis Evaluation of the ForteBio Octet RED: A Versatile Instrument for Direct Binding Experiments

Cooper, M., et al., Ch 15, Feb 24 Epub, Label-Free Technologies for Drug Discovery, 2011

This publication provides details of the Novartis evaluation of the Octet RED platform for kinetic characterization of small molecule and fragment binding to various proteins, which resulted in adoption of the system at Novartis. The Octet RED platform was evaluated against a number of platforms, including ITC and Biacore for small molecule screening and proper kinetic characterizations. The Octet RED platform gave binding constants and kinetics consistent with other enzymatic and biophysical methods. Primary, medium throughput assay for fragment-based screening was also possible on the Octet platform and produced reliable data.

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