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Moraxella catarrhalis Binds Plasminogen to Evade Host Innate Immunity

Singh B, et al., Epub ahead of print, Infect Immun, 2015

The article describes on a series of clinical isolates of the respiratory pathogen (Moraxella catarrhali) with the ability to attract plasminogen from human serum and causing an inactivation of complement components. Plasminogen interacts with surface protein A2 (UspA2) and a hybrid of UspA2 (UspA2H) that are present on the outer membrane of Moraxella. Bio-Layer Interferometry (BLI) was used to study the interaction between plasminogen and the bacterial proteins (UspA2 and UspA2H). A Pall ForteBio Octet RED96 instrument equipped with plasminogen immobilized Amine-Reactive (AR2G) biosensor probes was utilized in these experiments. Overall results suggest that the recruitment of plasminogen by M. catarrhalis may be contributing to increased virulence.

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