Modulation of In Vivo IgG Crystallization in the Secretory Pathway by Heavy Chain Isotype Class Switching and N-linked Glycosylation

Hasegawa H, et al., 1843(7):1325-1338, Biochim Biophys Acta, 2014

The authors performed screening and functional analysis to isolate and better characterize the regulatory mechanism of a second human IgG2 that has been linked to hematological disorder and disease conditions when it accumulates intracellularly and forms crystalline bodies. Human IgG concentration was determined on an Octet RED96 system. Protein A biosensors were used.

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