L-Citrulline Increases Hepatic Sensitivity to Insulin by Reducing the Phosphorylation of Serine 1101 in Insulin Receptor Substrate-1

Yoshitomi H, et al., 18;15:188, BMC Complement Altern Med, 2015

An investigation on the beneficial effects of L-citrulline (L-Cit) on improved insulin resistance is described. A Pall ForteBio Octet RED system equipped with Streptavidin Biosensor (SA) probes was used to determine the effect of L-Cit on insulin and its receptor (INSR) binding. The interaction between insulin and INSR was investigated in the presence and absence of L-Cit by capturing INSR on to SA biosensors.

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