Isolation and Optimization for Affinity and Biophysical Characteristics of Anti-CCL17 Antibodies from the VH1-69 Germline Gene

Kehoe JW, et al., doi: 10.1093/protein/gzu012, Protein Eng Des Sel, 2014

The authors described the screening of a targeted designed antibody library and the isolation and characterization of monoclonal variants with a high affinity to CCL17, a homeostatic chemokine associated with many human inflammatory diseases. Antibodies were characterized on the Octet system using Streptavidin biosensors.

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