Identify the Key Amino Acid of BAFF Binding with TACI

Wang R, et al., 284(1-2), 84-90, Cell Immunol, 2013

In this study, the key amino acids involved in the binding of B-cell activating factor (BAFF) to its receptor TACI were identified. TACI binding kinetics for various BAFF mutants were studied using the Octet RED system. BAFF receptor TACI-Ig was loaded onto Anti-Human IgG Capture biosensors for the determination of kon, koffand KD.

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