Identification of a Small Peptide that Inhibits PCSK9 Binding to the Low Density Lipoprotein Receptor

Zhang Y, et al., 289, 942-955, J Biol Chem, 2014

To identify a peptidic PCSK9 inhibitor, the authors screened phage-displayed peptide libraries and identified the 13-amino acid peptide, Pep2-8. Structural and biochemical characterization studies provided molecular details of its inhibitory mechanism. Affinities for Pep2-8_Fc and Pepctrl_Fc binding to PCSK9 were determined using the Octet RED384 system equipped with Anti-hIgG-Fc Capture biosensors loaded with Pep2-8_Fc or Pep-ctrl_Fc.

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