Normand A, Riviere E and Renodon-Corniere A,
pii: S0006-2952(14)00454-7,
Biochem Pharmacol,
2014
The authors screened the Prestwick library to identify small molecule candidates that will inhibit Rad51, a key protein involved in homologous recombination in eukaryotes and thought to be involved in chemo- and radio-resistance of human cancers by perturbing DNA repair processes. Binding of Rad51 to SS DNA was monitored using the Blitz system and ssDNA biosensors.
Read More