Publications

Identification and Characterization of Human Rad51 Inhibitors by Screening of an Existing Drug Library

Normand A, Riviere E and Renodon-Corniere A, pii: S0006-2952(14)00454-7, Biochem Pharmacol, 2014

The authors screened the Prestwick library to identify small molecule candidates that will inhibit Rad51, a key protein involved in homologous recombination in eukaryotes and thought to be involved in chemo- and radio-resistance of human cancers by perturbing DNA repair processes. Binding of Rad51 to SS DNA was monitored using the Blitz system and ssDNA biosensors.

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