Heterogeneous IgG Interacts with FcRn and Its Transport Across Gastrointestinal Barrier

Pang G, et al., DOI:10.1080/09540105.2014.918588, Food and Agricultural Immunology, 2015

This investigation focuses on the pathway for transporting of heterogeneous IgG across gastrointestinal barrier and hence to their destination in vivo upon consumption of IgG products from various mammalian origins. The human FcRn interactions with various IgG from different animal species were evaluated using a Pall ForteBio Octet RED system equipped with Streptavidin Biosensor probes. Biotinylated IgG captured on to the Streptavidin biosensors were used to bind human FcRn in solution. The results suggest that heterogeneous IgG could be transported into the blood stream by neonatal Fc receptor (FcRn).

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