Gel Filtration Chromatography as a Method for Removing Bacterial Endotoxin from Antibody Preparations

London AS, et al., doi: 10.1002/btpr.1961, Biotechnol Prog, 2014

The authors presented a method for removing endotoxins from antibody preparations both in the presences and absence of aggregates using gel filtration chromatography. The removal of endotoxins from biological samples is important due to their potent biologic activities causing pyrogenic and shock reactions in animals. Secondary screening was performed on the Octet RED384 system.

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