Factor VIII and von Willebrand Factor are Ligands for the Carbohydrate-Receptor Siglec-5

Pegon, J.N., et al., 97(12), 1855-63, Haematologica, 2012

Factor VIII and von Willebrand factor (VWF) are coagulation factors that exhibit sialylated glycan structures. This publication investigates the interactions of Factor VIII and VWF with Siglec-5 (sialic acid binding immunoglobulin-like lectin-5). Using the Octet QK system and dimeric sSiglet-5/Fc immobilized on Protein A biosensors, the authors show that both Factor VIII and VWF are able to interact with Siglec-5 with high affinity.

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