Enhancement of Tumor-specific T Cell-mediated Immunity in Dendritic Cell-based Vaccines by Mycobacterium Tuberculosis Heat Shock Protein X

Jung ID, et al., 193(3):1233-45, J Immunol, 2014

This report details the use of Heat Shock Protein (Hsp) X from Mycobacterium tuberculosis as a potent and strongly selective agonist for CTLs and is highly effective in the induction of T cell immunity as demonstrated by binding to pattern recognition receptor 4 (TLR4) and activating the TLR4 signaling pathway in dendritic cells (DC) in both in vitro and in vivo studies. These results suggest that Hsp X could be a potential adjuvant for dendritic cell-based antitumor immunotherapies. Binding studies were performed on the BLItz system using HIS biosensors.

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