Design, Synthesis, and Biological Evaluation of Novel FAK Scaffold Inhibitors Targeting the FAK-VEGFR3 Protein-protein Interaction

Gogate PN, et al., 80C:154-166, Eur J Med Chem., 2014

The authors designed, synthesized and screened for potent and selective tyrosine kinase inhibitors of focal adhesion kinase (FAK) and vascular endothelial growth factor receptor 3 (VEGFR3), two key modulators of survival and metastasis signaling in cancer cells. Binding studies were performed using Super Streptavidin biosensors and run on the Octet RED96 system.

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