Design of a Novel Cyclotide-Based CXCR4 Antagonist with Anti-Human Immunodeficiency Virus (HIV)-1 Activity

Aboye, T. L., et al., 55(23), 10729-34, J Med Chem, 2012

The authors describe the design and synthesis of a novel cyclotide able to inhibit the G-protein-coupled receptor CXCR4, a potential target for inhibition of HIV replication. To assess stability in human serum, the BLItz system was used to determine association and dissociation rate constants of the cyclotide to human serum proteins.

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