Publications

DC-SIGN Plays a Stronger Role than DCIR in Mediating HIV-1 Capture and Transfer

Jin W, et al., 458-459:83-92, Virology, 2014

The authors performed a systematic study comparing the capability between two C-type lectin receptors, DC-SIGN and DCIR expressed in dendritic cells in HIV-1 capture and transfer. Both receptors bind to gp-120 and contribute to HIV-1 capture and transfer but their mechanisms of actions differ slightly providing insight into targets for intervention. Binding kinetics were determined using the Octet RED system along with Streptavidin biosensors.

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