DC-SIGN Plays a Stronger Role than DCIR in Mediating HIV-1 Capture and Transfer

Jin W, et al., 458-459:83-92, Virology, 2014

The authors performed a systematic study comparing the capability between two C-type lectin receptors, DC-SIGN and DCIR expressed in dendritic cells in HIV-1 capture and transfer. Both receptors bind to gp-120 and contribute to HIV-1 capture and transfer but their mechanisms of actions differ slightly providing insight into targets for intervention. Binding kinetics were determined using the Octet RED system along with Streptavidin biosensors.

Read More