Cyclic di-GMP Sensing via the Innate Immune Signaling Protein STING

Yin, Q., et al., 46 (6), 735-745, Molecular Cell, 2012

The structural characteristics of STING (stimulator of interferon genes) cytosolic domain are investigated in this publication. The BLItz system was used to study binding between STING CBD (c-di-GMP binding domain) and IKK-like kinase TBK1. Biotinylated CBD was immobilized on Streptavidin biosensors and incubated with various concentrations of TBK1.

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