Crystal Structure of the Hendra Virus Attachment G Glycoprotein Bound to a Potent Cross-reactive Neutralizing Human Monoclonal Antibody

Xu K, et al., 9(10):e1003684, PLoS Pathog, 2013

This study reports the crystal structure of the complex of Hendra Virus G (HeV-G) glycoprotein with human mAb m102.3, an m102.4 derivative, and describes NiV and HeV escape mutants. Binding kinetics for wild type or mutant G proteins to m102.3 and m102.4 antibodies or to ephrin-B2 were measured using the BLItz system. Ni-NTA biosensors were used to immobilize the hexa-Histidine fused antibodies and ephrin-B2 proteins.

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