Publications

Bioreactor Process Parameter Screening Utilizing a Plackett-Burman Design for a Model Monoclonal Antibody Measurement

Agarabi C, et al., 104(6):1919-28, J Pharm Sci, 2015

The authors report the use of Plackett-Burman design to screen cell culture parameters and highlight the importance of eleven different variables toward achieving this goal. In particular, the authors found temperature variations could affect glycan-modification and distribution profiles. This approach is expected to be useful in monoclonal antibody manufacturing processes. IgG3 antibody quantitation was achieved by a Pall ForteBio Octet RED96 system equipped with Protein A biosensor probes.

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