Antibacterial Activity and Mechanism of a Scorpion Venom Peptide Derivative In Vitro and In Vivo

L. Cao, et al., 7(7), e40135, PLoS One, 2012

The authors derived a peptide (Kn2-7) from the scorpion venom antimicrobial peptide BmKn2. The Kn2-7 peptide showed increased antimicrobial activity and decreased hemolytic activity relative to BmKn2. Results from in vitro and in vivo assays indicated that Kn2-7 shows promise as a topical therapeutic agent for treating bacterial infections. The Octet RED system was used to identify the targets for Kn2-7 in S. aureus and E. coli. Streptavidin biosensors and biotinylated Kn2-7 were used for the binding studies.

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