A Strategy for Clone Selection Under Different Production Conditions

Legmann, R., et al., 27 (3), 757-765, Biotechnology Progress, 2011

The authors report on a strategy for dynamic ranking of clones in micro-bioreactors. Multiple clones in multiple culture conditions were monitored for maximum cell density, growth, and titer. The Octet QK system with Protein A biosensors was used for high-throughput determination of Mab concentrations in the crude culture supernatants.

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